Evidence map›Paper›PMID 31341226›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Neurodevelopmental outcomes in infants treated with intravitreal bevacizumab versus laser.

Kamini Raghuram, Maram Isaac, Junmin Yang, Alaa AlAli, Kamiar Mireskandari, Linh G Ly, Edmond Kelly, Rudaina Banihani, Prakesh S Shah, Nasrin Tehrani

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Neurodevelopmental outcomes following bevacizumab treatment for retinopathy of prematurity: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Pooled it
  5. Article
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  16. Neurodevelopmental outcomes following bevacizumab treatment for retinopathy of prematurity: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  17. Hypertension in neonates treated with intravitreal bevacizumab for retinopathy of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  18. PFKFB3: A Potential Key to Ocular Angiogenesis.Frontiers in cell and developmental biology · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kamini RaghuramDivision of Neonatology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Maram IsaacDepartment of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
Junmin YangDepartment of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Alaa AlAliDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Kamiar MireskandariDepartment of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
Linh G LyDivision of Neonatology Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Edmond KellyDepartment of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Rudaina BanihaniDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
Nasrin TehraniDepartment of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada. Nasrin.tehrani@sickkids.ca.
University of Toronto · CAHospital for Sick Children · CAMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare neurodevelopmental and visual outcomes in preterm infants treated with intravitreal bevacizumab (IVB) to laser ablation at 18-24 months corrected age. STUDY

designA retrospective study was performed. The primary outcome was neurodevelopmental impairment (NDI). Secondary neurodevelopmental outcomes were significant NDI (sNDI), cerebral palsy, hearing loss, and composite scores of the Bayley Scales of Infant Development, Third edition. Visual outcomes included structural and refractive outcomes. Adjusted odds ratios (AOR) were calculated controlling for GA, sex, and ROP severity and confounding baseline characteristics using a cutoff of p < 0.20.

resultsThirty-four (60 eyes) infants receiving IVB and 30 (51 eyes) laser were included. No significant differences were identified in NDI (AOR 1.77, 95% CI 0.46, 6.73) or sNDI (AOR 2.31, 95% CI 0.75, 7.14). There were no other differences in outcomes.

conclusionsLarger randomized trials are required to establish long-term efficacy and safety of IVB in preterm neonates.

Indexed as

Laser TherapyAngiogenesis InhibitorsBevacizumabChild DevelopmentHumansInfantInfant, PrematureNeurodevelopmental DisordersRetinopathy of PrematurityRetrospective StudiesVision, OcularAngiogenesis InhibitorsBevacizumab

Identifiers

PMID31341226
OpenAlexW2963022236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.