Evidence map›Paper›PMID 31341212›Full record

ArticleScientific reports2019

Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer.

Surrin S Deen, Andrew N Priest, Mary A McLean, Andrew B Gill, Cara Brodie, Robin Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine Parkinson and 11 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Comparing Characteristics of Pelvic High-grade Serous Carcinomas with and without Breast Cancer Gene Variants on MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Assessing Histology Structures byFrontiers in oncology · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Surrin S DeenDepartment of Radiology, Box 218, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom. ssd32@cam.ac.uk.
Andrew N PriestCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.ORCID http://orcid.org/0000-0002-9771-4290
Mary A McLeanCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom.
Andrew B GillDepartment of Radiology, Box 218, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Cara BrodieCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom.
Robin CrawfordCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
John LatimerCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Peter BaldwinCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Helena M EarlDepartment of Radiology, Box 218, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Christine ParkinsonCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Sarah SmithCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Charlotte HodgkinCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Ilse PattersonCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Helen AddleyCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Susan FreemanCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Penny MoyleCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Mercedes Jimenez-LinanCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.
Martin J GravesCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.ORCID http://orcid.org/0000-0003-4327-3052
Evis SalaDepartment of Radiology, Box 218, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
James D BrentonCambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom.ORCID http://orcid.org/0000-0002-5738-6683
Ferdia A GallagherDepartment of Radiology, Box 218, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.ORCID http://orcid.org/0000-0003-4784-5230
Cambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

Cancer Research UK 16628Cancer Research UK 22905Cancer Research UK 27150
6 · The paper itself

Abstract

This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant chemotherapy (NACT). Seventeen patients with HGSOC were imaged at 3 T and had biopsy samples taken prior to any treatment. The patients were divided into two groups: responders and non-responders based on Response Evaluation Criteria In Solid Tumours (RECIST) criteria. The following imaging metrics were calculated: apparent diffusion coefficient (ADC), apparent diffusion (D

Indexed as

AdultAgedAged, 80 and overCystadenocarcinoma, SerousDiffusion Magnetic Resonance ImagingEnvironmental BiomarkersFemaleHumansMiddle AgedNeoadjuvant TherapyOvarian NeoplasmsOvaryTreatment OutcomeEnvironmental Biomarkers

Identifiers

PMID31341212
PMCPMC6656714
OpenAlexW2958071656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.