ArticleScientific reports2019
Cascade biotransformation of estrogens by Isaria fumosorosea KCh J2.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Biotransformation of ΔInternational journal of molecular sciences · 2023Article
- Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products' Bioactivity.International journal of molecular sciences · 2023Article
- Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic StrainInternational journal of molecular sciences · 2022Article
- New 6,19-oxidoandrostan derivatives obtained by biotransformation in environmental filamentous fungi cultures.Microbial cell factories · 2020Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrone, estradiol, ethynylestradiol and estrone 3-methyl ether underwent a biotransformation process in the submerged culture of Isaria fumosorosea KCh J2. Estrone was transformed into seven metabolites, four of which were glycosylated. Estradiol was selectively glycosylated at C-3 and then transformed to D-ring lactone. Ethynylestradiol was coupled with methylglucoside and 6β-hydroxyderivative was obtained. Estrone 3-methyl ether was not transformed indicating that a free hydroxyl group at C-3 is necessary for glycosylation. Baeyer-Villiger oxidation combined with hydroxylation and glycosylation was observed. All glycosides obtained in this study are 3-O-β-methylglucosides.
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Registered trials
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