ArticleScientific reports2019
Etiology and Outcome of non-immune Hydrops Fetalis in Southern China: report of 1004 cases.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 27 citations in OpenAlex.
- Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series.Future science OA · 2026Article
- 22q11.2 duplication syndrome and LZTR1-related Noonan syndrome type 10 overlapping phenotypes in a dual diagnosis - fetal hydrops: a case report.BMC pregnancy and childbirth · 2026Article
- Immune and non-immune hydrops fetalis in a Saudi tertiary center: etiologies, antenatal predictors, perinatal outcomes, and one-year survival in a seven-year cohort.Frontiers in pediatrics · 2026Article
- Isolated non-immune hydrops fetalis: an observational study on complete spontaneous resolution, perinatal outcome, and long-term follow-up.Archives of gynecology and obstetrics · 2023Observational
- Genetic disorders and pregnancy outcomes of non-immune hydrops fetalis in a tertiary referral center.BMC medical genomics · 2023Article
- Clinical characteristics and risk factors of mirror syndrome: a retrospective case-control study.BMC pregnancy and childbirth · 2021Article
- Frequency and Prognosis of Hydrops Fetalis: A 10-Year Single-Center Experience.Sisli Etfal Hastanesi tip bulteni · 2021Article
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Authors and funding
16 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Non-immune hydrops fetalis (NIHF) is a complex condition with a high mortality and morbidity rate. Here we report the etiology and outcome of 1004 fetuses with NIHF, in a large single Maternal and Children's hospital of Southern China, since the year of 2009 to 2016. Among these 1004 fetuses with NIHF, the etiology was identified prenatally in 722 of them (72%). The most common ones were hematologic diseases and chromosomal abnormalities. There were eight spontaneous abortions, 18 intrauterine fetal demise, 672 pregnancy terminations and 87 were lost to follow-up. 219 of the 1004 fetuses were live-born and the overall survival rate was 21.8% at this point. After birth 16 perinatal or early neonatal deaths were encountered and five lost to follow-up. Of the remaining 198 newborns, 153 thrived without apparent morbidity. The most significant factors associated with mortality were prematurity and low birthweight. In conclusion, we described the largest report of underlying causes and outcome of NIHF in Southern China. Etiologies were identified for 72% of 1004 fetuses with NIHF. And two poor prognostic factors for survival are preterm birth at less than 36.5 weeks and birthweight lower than 2575 g respectively.
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