ArticleProceedings of the National Academy of Sciences of the United States of America2019
Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78 citing papers in PubMed, 144 citations in OpenAlex.
- Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation.Scientific reports · 2020Trial
- Frequency-Specific EEG burst dynamics in Parkinson's Disease and freezing of gait.Journal of neurology · 2026Article
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Active inference and artificial reasoning.Nature communications · 2026Article
- Bidirectional EEG Neurofeedback of Sensorimotor Beta Oscillations Reveals Asymmetric Modulation and Strategy-Dependent Learning.The European journal of neuroscience · 2026Article
- Aberrant Gamma Oscillations in Parkinson's Disease.Neuroscience bulletin · 2026Review
- Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations.PLoS computational biology · 2026Article
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
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- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.Journal of neural engineering · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.medRxiv : the preprint server for health sciences · 2025Article
- Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.Nature communications · 2025Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- Common and Unique Neurophysiological Processes That Support the Stopping and Revising of Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Beta frequency oscillations (15 to 35 Hz) in cortical and basal ganglia circuits become abnormally synchronized in Parkinson's disease (PD). How excessive beta oscillations emerge in these circuits is unclear. We addressed this issue by defining the firing properties of basal ganglia neurons around the emergence of cortical beta bursts (β bursts), transient (50 to 350 ms) increases in the beta amplitude of cortical signals. In PD patients, the phase locking of background spiking activity in the subthalamic nucleus (STN) to frontal electroencephalograms preceded the onset and followed the temporal profile of cortical β bursts, with conditions of synchronization consistent within and across bursts. Neuronal ensemble recordings in multiple basal ganglia structures of parkinsonian rats revealed that these dynamics were recapitulated in STN, but also in external globus pallidus and striatum. The onset of consistent phase-locking conditions was preceded by abrupt phase slips between cortical and basal ganglia ensemble signals. Single-unit recordings demonstrated that ensemble-level properties of synchronization were not underlain by changes in firing rate but, rather, by the timing of action potentials in relation to cortical oscillation phase. Notably, the preferred angle of phase-locked action potential firing in each basal ganglia structure was shifted during burst initiation, then maintained stable phase relations during the burst. Subthalamic, pallidal, and striatal neurons engaged and disengaged with cortical β bursts to different extents and timings. The temporal evolution of cortical and basal ganglia synchronization is cell type-selective, which could be key for the generation/ maintenance of excessive beta oscillations in parkinsonism.
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