Evidence map›Paper›PMID 31341074›Full record

ArticlemSphere2019

Enterococcus faecalis CRISPR-Cas Is a Robust Barrier to Conjugative Antibiotic Resistance Dissemination in the Murine Intestine.

Valerie J Price, Sara W McBride, Karthik Hullahalli, Anushila Chatterjee, Breck A Duerkop, Kelli L Palmer

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
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  5. Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
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  12. CRISPR-Cas systems in enterococci.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Valerie J PriceDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Sara W McBrideDepartment of Immunology & Microbiology, The University of Colorado School of Medicine, Aurora, Colorado, USA.
Karthik HullahalliDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Anushila ChatterjeeDepartment of Immunology & Microbiology, The University of Colorado School of Medicine, Aurora, Colorado, USA.
Breck A DuerkopDepartment of Immunology & Microbiology, The University of Colorado School of Medicine, Aurora, Colorado, USA breck.duerkop@ucdenver.edu kelli.palmer@utdallas.edu.ORCID 0000-0003-4030-9822
Kelli L PalmerDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA breck.duerkop@ucdenver.edu kelli.palmer@utdallas.edu.ORCID 0000-0002-7343-9271
The University of Texas at Dallas · USUniversity of Colorado Denver · US

Funding

Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.R01AI141479 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DUERKOP, BRECK A · 2018 to 2025
$4.4M
Genome defense and acquired antibiotic resistance in Enterococcus faecalis and Enterococcus faeciumR01AI116610 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI PALMER, KELLI LEA · 2015 to 2019
$1.9M
The contribution of bacteriophages to host-microbe interactions in the intestineK01DK102436 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DUERKOP, BRECK A · 2014 to 2018
$581k
NIAID NIH HHS R01 AI116610NIAID NIH HHS R01 AI141479NIDDK NIH HHS K01 DK102436
6 · The paper itself

Abstract

CRISPR-Cas systems are barriers to horizontal gene transfer (HGT) in bacteria. Little is known about CRISPR-Cas interactions with conjugative plasmids, and studies investigating CRISPR-Cas/plasmid interactions in

Indexed as

Conjugation, GeneticCRISPR-Cas SystemsDrug Resistance, BacterialGene Transfer, HorizontalAnimalsAnti-Bacterial AgentsEnterococcus faecalisIntestinesMiceMice, Inbred C57BLPlasmidsAnti-Bacterial Agentsantibiotic resistanceCRISPR-CasEnterococcus faecalisintestinal colonizationplasmids

Identifiers

PMID31341074
PMCPMC6656873
OpenAlexW2963369031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.