ArticleJournal of virology2019
Frog Virus 3 Genomes Reveal Prevalent Recombination between Ranavirus Lineages and Their Origins in Canada.
Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Environmental Drivers of Ranavirus Infection in Anurans of the Brazilian Atlantic Forest.EcoHealth · 2026Article
- Genomic Analysis of Megalocytivirus Genomes Reveals Widespread Recombination.Genome biology and evolution · 2026Article
- IVCDB: a comprehensive database of iridoviruses for epidemiology, genetic evolution, and disease management.Nucleic acids research · 2026Article
- Genomic analysis ofbioRxiv : the preprint server for biology · 2025Article
- Continent-Wide Distribution of CMTV-Like Ranavirus, from the Urals to the Atlantic Ocean.EcoHealth · 2025Article
- Engineering iridoviruses: development of reverse genetics and virus rescue systems.Journal of virology · 2025Article
- Article
- First Report of Endemic Frog Virus 3 (FV3)-like Ranaviruses in the Korean Clawed Salamander (Viruses · 2024Article
- Article
- Genome Characteristics of Two Ranavirus Isolates from Mandarin Fish and Largemouth Bass.Pathogens (Basel, Switzerland) · 2023Article
- Article
- Article
- Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture.Cell & bioscience · 2022Article
- Ranavirus Amplification in Low-Diversity Amphibian Communities.Frontiers in veterinary science · 2022Article
- Patterns of infection, origins, and transmission of ranaviruses among the ectothermic vertebrates of Asia.Ecology and evolution · 2021Review
- Article
- Targeted Transcriptomics of Frog Virus 3 in Infected Frog Tissues Reveal Non-Coding Regulatory Elements and microRNAs in the Ranaviral Genome and Their Potential Interaction with Host Immune Response.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ranaviruses are pathogens associated with the decline of amphibian populations across much of their distribution. In North America, frog virus 3 (FV3) is a widely distributed pathogen with wild populations of amphibians harboring different lineages and putative recombinants between FV3 and common midwife toad virus (CMTV). These recombinants have higher pathogenicity, and CMTV-derived genes associated with virulence are reported in wild strains in Canada. However, while FV3 is linked to amphibian die-offs in North America, CMTVs have been reported only in commercial frog farms in North America. We sequenced complete genomes of 18 FV3 isolates from three amphibian species to characterize genetic diversity of the lineages in Canada and infer possible recombinant regions. The 18 FV3 isolates displayed different signals of recombination, varying from none to interspersed recombination with previously isolated CMTV-like viruses. In general, most recombination breakpoints were located within open reading frames (ORFs), generating new ORFs and proteins that were a mixture between FV3 and CMTV. A combined spatial and temporal phylogeny suggests the presence of the FV3 lineage in Canada is relatively contemporary (<100 years), corroborating the hypothesis that both CMTV- and FV3-like viruses spread to North America when the international commercial amphibian trade started. Our results highlight the importance of pathogen surveillance and viral dynamics using full genomes to more clearly understand the mechanisms of disease origin and spread.
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