Evidence map›Paper›PMID 31341050›Full record

ArticleJournal of virology2019

Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice.

Rebecca S Treger, Maria Tokuyama, Huiping Dong, Karen Salas-Briceno, Susan R Ross, Yong Kong, Akiko Iwasaki

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. T-betNature communications · 2024
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  13. Retroviruses drive the rapid evolution of mammalianProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rebecca S TregerDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Maria TokuyamaDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Huiping DongDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Karen Salas-BricenoDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Susan R RossDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3094-3769
Yong KongDepartment of Molecular Biophysics and Biochemistry, W. M. Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, Connecticut, USA.
Akiko IwasakiDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA akiko.iwasaki@yale.edu.ORCID 0000-0002-7824-9856
Yale University · USUniversity of Illinois Chicago · USHoward Hughes Medical Institute · USW. M. Keck Foundation · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Immunity to Genital Herpes Simplex-2R01AI054359 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2004 to 2019
$5.2M
Role of APOBEC3 in in vivo Restriction of Retrovirus InfectionR01AI085015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 2010 to 2019
$3.9M
B cell based protection against recurrent herpesR01AI127429 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2017 to 2021
$2.1M
Cell-intrinsic mechanisms of endogenous retroviral controlF30AI129265 · NIAID · YALE UNIVERSITY · PI TREGER, REBECCA · 2017 to 2019
$108k
Howard Hughes Medical InstituteNIAID NIH HHS F30 AI129265NIAID NIH HHS R01 AI054359NIAID NIH HHS R01 AI085015NIAID NIH HHS R01 AI127429NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Endogenous retroviruses (ERV) are found throughout vertebrate genomes, and failure to silence their activation can have deleterious consequences on the host. Mutation and subsequent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses that maintain the integrity of the host genome. Abundant

Indexed as

Virus ReplicationAnimalsAPOBEC-3G DeaminaseEndogenous RetrovirusesGene DosageHost-Pathogen InteractionsImmunity, InnateMiceMice, KnockoutOpen Reading FramesRetroviridae InfectionsToll-Like ReceptorsAPOBEC-3G DeaminaseAPOBEC3G protein, mouseToll-Like ReceptorsAPOBECinnate immunityretrovirusesToll-like receptors

Identifiers

PMID31341050
PMCPMC6798113
OpenAlexW2963077001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.