Evidence map›Paper›PMID 31341018›Full record

ArticleThe Journal of biological chemistry2019

MtpB, a member of the MttB superfamily from the human intestinal acetogen

Jonathan W Picking, Edward J Behrman, Liwen Zhang, Joseph A Krzycki

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  5. Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  9. Review
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  15. Isolation and characterization of a novel choline degradingCurrent research in microbial sciences · 2022
    Article
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  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jonathan W PickingOhio State Biochemistry Program, Ohio State University, Columbus, Ohio 43210.
Edward J BehrmanDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio 43210.ORCID 0000-0002-8797-6625
Liwen ZhangCampus Chemical Instrument Center Mass Spectrometry and Proteomics Facility, Ohio State University, Columbus, Ohio 43210.
Joseph A KrzyckiOhio State Biochemistry Program, Ohio State University, Columbus, Ohio 43210 Krzycki.1@osu.edu.
The Ohio State University · US

Funding

Alternative routes of gut microbial methylamine metabolism that may limit trimethylamine N-oxide, a trigger for atherosclerosis.R01DK109345 · NIDDK · OHIO STATE UNIVERSITY · PI KRZYCKI, JOSEPH ADRIAN · 2016 to 2020
$2.2M
Acquisition of a Next Generation Orbitrap MSS10OD018056 · OD · OHIO STATE UNIVERSITY · PI FREITAS, MICHAEL A. · 2014 to 2014
$573k
NIDDK NIH HHS R01 DK109345NIH HHS S10 OD018056
6 · The paper itself

Abstract

The trimethylamine methyltransferase MttB is the founding member of a widely distributed superfamily of microbial proteins. Genes encoding most members of the MttB superfamily lack the codon for pyrrolysine that distinguishes previously characterized trimethylamine methyltransferases, leaving the function(s) of most of the enzymes in this superfamily unknown. Here, investigating the MttB family member MtpB from the human intestinal isolate

Indexed as

BetaineDemethylationEnergy MetabolismEubacteriumFolic AcidHumansIntestinesMethylaminesMethylationMethyltransferasesMicrobiotaProlineTetrahydrofolates5,6,7,8-tetrahydrofolic acidBetaineFolic AcidMethylaminesMethyltransferasesN-methylprolineProlineTetrahydrofolatestrimethylamineacetogenesisbacterial metabolismcobalaminenergy metabolismenzyme catalysisfolatemicrobiologymicrobiomeone-carbon metabolismtrimethylamine methyltransferase

Identifiers

PMID31341018
PMCPMC6746465
OpenAlexW2963424761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.