Evidence map›Paper›PMID 31341016›Full record

ArticleThe Journal of biological chemistry2019

The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3-induced cell cycle arrest.

R Sergio Solorzano-Vargas, Matthew Bjerknes, S Vincent Wu, Jiafang Wang, Matthias Stelzner, James C Y Dunn, Sangeeta Dhawan, Hazel Cheng, Senta Georgia, Martín G Martín

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Article
  4. Epigenetic Regulation of Pancreas Development and Function.Advances in anatomy, embryology, and cell biology · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

R Sergio Solorzano-VargasDepartment of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children's Hospital and the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095.
Matthew BjerknesDepartment of Medicine, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
S Vincent WuVeterans Affairs Greater Los Angeles Healthcare System, and Department of Medicine, University of California, Los Angeles, Los Angeles, California 90073.
Jiafang WangDepartment of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children's Hospital and the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095.
Matthias StelznerDivision of General Surgery, Department of Surgery, University of California, Los Angeles, Los Angeles, California 90095.
James C Y DunnDivision of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305.
Sangeeta DhawanDepartment of Translational Research and Cellular Therapeutics, City of Hope, Duarte, California 91010.
Hazel ChengDepartment of Medicine, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Senta GeorgiaDepartment of Pediatrics, Division of Endocrinology, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, Los Angeles, California 90027.
Martín G MartínDepartment of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children's Hospital and the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 mmartin@mednet.ucla.edu.ORCID 0000-0002-7192-0504
University of California, Los Angeles · USUniversity of Toronto · CACity of Hope · USStanford University · USUniversity of Southern California · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Intestinal Stem Cell Culture and Entero-Endocrine Lineage DevelopmentU01DK085535 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNN, JAMES C, MARTIN, MARTIN G · 2009 to 2018
$3.7M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Neurogenin3 and Intestinal FailureR01DK083762 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2009 to 2012
$1.6M
NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK083762NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK085535NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

Neurogenin-3 (NEUROG3) is a helix-loop-helix (HLH) transcription factor involved in the production of endocrine cells in the intestine and pancreas of humans and mice. However, the human NEUROG3 loss-of-function phenotype differs subtly from that in mice, but the reason for this difference remains poorly understood. Because

Indexed as

Cell Cycle CheckpointsBasic Helix-Loop-Helix ProteinsCell LineCellular SenescenceGene Expression RegulationGenes, p16HumansMitogen-Activated Protein Kinase 7Nerve Tissue ProteinsProto-Oncogene MasPTEN PhosphohydrolaseBasic Helix-Loop-Helix ProteinsMAPK7 protein, humanMAS1 protein, humanMitogen-Activated Protein Kinase 7Nerve Tissue ProteinsNEUROG3 protein, humanProto-Oncogene MasPTEN Phosphohydrolasebasic helix-loop-helix transcription factor (bHLH)endocrinologyintestinal epitheliumneuroendocrinologypancreatic islet

Identifiers

PMID31341016
PMCPMC6791307
OpenAlexW2963083576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.