ArticleNeurology2019
Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study.
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Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
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- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies.Journal of obesity · 2023Pooled it
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
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- Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits.PLoS genetics · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- The WFS1-ZnT3-ZnAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community.Journal of Alzheimer's disease : JAD · 2024Article
- Association of obesity indicators with cognitive function among US adults aged 60 years and older: Results from NHANES.Brain and behavior · 2024Article
- Towards a Deeper Understanding: Utilizing Machine Learning to Investigate the Association between Obesity and Cognitive Decline-A Systematic Review.Journal of clinical medicine · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Associations between adiposity and white matter hyperintensities: Cross-sectional and longitudinal analyses of 34,653 participants.Human brain mapping · 2024Article
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- Adherence to a healthy lifestyle and brain structural imaging markers.European journal of epidemiology · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
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- The Waist-Hip Ratio is a Mediator Between Serum Levels of Brain-Derived Neurotrophic Factor and Its Val66Met Polymorphism in Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.Bipolar disorders · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Michelle R CauncaFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Hannah GardenerFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Marialaura SimonettoFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Ying Kuen CheungFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Noam AlperinFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Mitsuhiro YoshitaFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.ORCID 0000-0001-5979-8385
Charles DeCarliFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Mitchell S V ElkindFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Ralph L SaccoFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Clinton B WrightFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD.
Tatjana RundekFrom the Division of Epidemiology and Population Health Sciences, Department of Public Health Sciences (M.R.C.), Department of Neurology (M.R.C., H.G., M.S., R.L.S., T.R.), and Department of Radiology (N.A.), Miller School of Medicine, and Evelyn F. McKnight Brain Institute (M.R.C., N.A., R.L.S., T.R.), University of Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, and Department of Neurology, Vagelos College of Physicians and Surgeons (M.S.V.E.), Columbia University, New York, NY; Department of Neurology (M.Y.), Hokuriku National Hospital, Nanto, Japan; Department of Neurology (C.D.), University of California, Davis; and National Institute of Neurological Disorders and Stroke (C.B.W.), Bethesda, MD. trundek@med.miami.edu.
Oregon Health & Science University · US
Funding
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2MEffects of White and Gray Matter Integrity on Cognition in A Multi-Ethnic CohortF30NS103462 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CAUNCA, MICHELLE RAE · 2017 to 2020
$199kNINDS NIH HHS F30 NS103462NINDS NIH HHS R01 NS029993
Abstract
objectiveTo examine associations between measures of obesity in middle to early-old age with later-life MRI markers of brain aging.
methodsWe analyzed data from the Northern Manhattan MRI Sub-Study (n = 1,289). Our exposures of interest were body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and plasma adiponectin levels. Our outcomes of interest were total cerebral volume (TCV), cortical thickness, white matter hyperintensity volume (WMHV), and subclinical brain infarcts (SBI). Using multivariable linear and logistic regression models adjusted for sociodemographics, health behaviors, and vascular risk factors, we estimated β coefficients (or odds ratios) and 95% confidence intervals (CIs) and tested interactions with age, sex, and race/ethnicity.
resultsOn average at baseline, participants were aged 64 years and had 10 years of education; 60% were women and 66% were Caribbean Hispanic. The mean (SD) time lag between baseline and MRI was 6 (3) years. Greater BMI and WC were significantly associated with thinner cortices (BMI β [95% CI] -0.089 [-0.153, -0.025], WC β [95% CI] -0.103 [-0.169, -0.037]) in fully adjusted models. Similarly, compared to those with BMI <25, obese participants (BMI ≥30) exhibited smaller cortical thickness (β [95% CI] -0.207 [-0.374, -0.041]). These associations were particularly evident for those aged <65 years. Similar but weaker associations were observed for TCV. Most associations with WMHV and SBI did not reach statistical significance.
conclusionsAdiposity in early-old age is related to reduced global gray matter later in life in this diverse sample. Future studies are warranted to elucidate causal relationships and explore region-specific associations.
Indexed as
AdiponectinAgedAgingAtrophyBiomarkersBody SizeBrainBrain InfarctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingObesityWhite MatterAdiponectinBiomarkers
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