Trial reportBMC pulmonary medicine2019
Asthma rehabilitation at high vs. low altitude: randomized parallel-group trial.
Trial report in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02741583 (Asthma Rehabilitation at High vs. Low Altitude), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asthma Rehabilitation at High vs. Low Altitude: Randomized Controlled Parallel-group Trial
Who cites it
8 citing papers in PubMed.
- Exercise Dysfunction and Pulmonary Rehabilitation Strategies in COPD Patients at High-Altitudes: A Review.International journal of chronic obstructive pulmonary disease · 2025Review
- Validation of the CaReQoL asthma: a patient reported outcome measure for monitoring the perceived effects of pulmonary rehabilitation in adult patients with severe refractory asthma.Respiratory research · 2023Article
- Echocardiography and extravascular lung water during 3 weeks of exposure to high altitude in otherwise healthy asthmatics.Frontiers in physiology · 2023Article
- Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper.Allergy · 2022Article
- Sex differences during a cold-stress test in normobaric and hypobaric hypoxia: A randomized controlled crossover study.Frontiers in physiology · 2022Article
- The Oxygen Transport Triad in High-Altitude Pulmonary Edema: A Perspective from the High Andes.International journal of environmental research and public health · 2021Article
- Defining a role for exercise training in the management of asthma.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Physical Activity: A Missing Link in Asthma Care.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundTo investigate the effect of asthma rehabilitation at high altitude (3100 m, HA) compared to low altitude (760 m, LA).
methodsFor this randomized parallel-group trial insufficiently controlled asthmatics (Asthma Control Questionnaire (ACQ) > 0.75) were randomly assigned to 3-week in-hospital rehabilitation comprising education, physical-&breathing-exercises at LA or HA. Co-primary outcomes assessed at 760 m were between group changes in peak expiratory flow (PEF)-variability, and ACQ) from baseline to end-rehabilitation and 3 months thereafter.
results50 asthmatics were randomized [median (quartiles) LA: ACQ 2.7(1.7;3.2), PEF-variability 19%(14;33); HA: ACQ 2.0(1.6;3.0), PEF-variability 17%(12;32)]. The LA-group improved PEF-variability by median(95%CI) -7%(- 14 to 0, p = 0.033), ACQ - 1.4(- 2.2 to - 0.9, p < 0.001), and after 3 months by - 3%(- 18 to 2, p = 0.103) and - 0.9(- 1.3 to - 0.3, p = 0.002). The HA-group improved PEF-variability by - 10%(- 21 to - 3, p = 0.004), ACQ - 1.1(- 1.3 to - 0.7, p < 0.001), and after 3 months by - 9%(- 10 to - 3, p = 0.003) and - 0.2(- 0.9 to 0.4, p = 0.177). The additive effect of HA vs. LA directly after the rehabilitation on PEF-variability was - 6%(- 14 to 2), on ACQ 0.3(- 0.4 to 1.1) and after 3 months - 5%(- 14 to 5) respectively 0.4(- 0.4 to 1.1), all p = NS.
conclusionAsthma rehabilitation is highly effective in improving asthma control in terms of PEF-variability and symptoms, both at LA and HA similarly.
trial registrationClinicaltrials.gov: NCT02741583, Registered April 18, 2016.
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