Evidence map›Paper›PMID 31340678›Full record

ArticleDrug delivery2019

Zinc oxide end-capped Fe

Minchao Liu, Xiangyu Sun, Zhihui Liao, Yahui Li, Xiaoliang Qi, Yuna Qian, Hicham Fenniri, Ping Zhao, Jianliang Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minchao Liua School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University , Wenzhou , China.
Xiangyu Sunb School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou , China.
Zhihui Liaob School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou , China.
Yahui Lia School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University , Wenzhou , China.
Xiaoliang Qia School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University , Wenzhou , China.
Yuna Qianc Wenzhou Institute, University of Chinese Academy of Sciences , Wenzhou , China.
Hicham Fennirid Department of Chemical Engineering, Northeastern University , Boston , MA , USA.
Ping Zhaob School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou , China.
Jianliang Shena School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University , Wenzhou , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional core-shell nanocarriers based on zinc oxide (ZnO)-gated magnetic mesoporous silica nanoparticles (MMSN) were prepared for cancer treatment through magnetic targeting and pH-triggered controlled drug release. Under an external magnetic field, the MMSN could actively deliver chemotherapeutic agent, daunomycin (DNM), to the targeted sites. At neutral aqueous, the functionalized MMSN could stably accommodate the DNM molecules since the mesopores were capped by the ZnO gatekeepers. In contrast, at the acid intercellular environment, the gatekeepers would be removed to control the release of drugs due to the dissolution of ZnO. Meanwhile, ZnO quantum dots not only rapidly dissolve in an acidic condition of cancer cells but also enhance the anti-cancer effect of Zn

Indexed as

Antibiotics, AntineoplasticCell SurvivalDaunorubicinDrug Delivery SystemsDrug LiberationHeLa CellsHumansHydrogen-Ion ConcentrationIonsMagnetite NanoparticlesPorosityQuantum DotsSilicon DioxideZinc OxideAntibiotics, AntineoplasticDaunorubicinIonsMagnetite NanoparticlesSilicon DioxideZinc OxidedaunomycinMagnetic mesoporous silica nanoparticlespH-responsivesynergistic effectsZnO

Identifiers

PMID31340678
PMCPMC6713220

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.