Evidence map›Paper›PMID 31340676›Full record

ArticleDrug delivery2019

Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma.

Tao Liu, Jingzhen Li, Xidong Wu, Siyi Zhang, Zhongming Lu, Guanxue Li, Junzheng Li, Shaohua Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  9. Use of graphene-based materials as carriers of bioactive agents.Asian journal of pharmaceutical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tao Liua Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
Jingzhen Lib Department of Nephrology, Ningbo Yinzhou Second Hospital , Ningbo , China.
Xidong Wuc Department of Pharmacology, Jiangxi Testing Center of Medical Instruments , Nanchang , China.
Siyi Zhanga Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
Zhongming Lua Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
Guanxue Lid Department of Pediatric Center, Zhujiang Hospital of Southern Medical University , Guangzhou , China.
Junzheng Lie Department of Otolaryngology-Head and Neck Surgery, The Affiliated Dongguan Hospital of Jinan University , Dongguan , China.
Shaohua Chena Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.
Guangdong Provincial People's Hospital · CNNingbo No. 2 Hospital · CNGuangdong Academy of Medical Sciences · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by

Indexed as

3T3 CellsAminesAnimalsAntineoplastic AgentsCell Line, TumorCombined Modality TherapyDocetaxelDrug CarriersDrug Delivery SystemsGenetic TherapyGene Transfer TechniquesGlutathioneGraphiteMatrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMiceAminesAntineoplastic AgentsDocetaxelDrug CarriersGlutathionegraphene oxideGraphiteMatrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsRNA, Small InterferingTransferrindrug and gene co-deliverygraphene oxideGSH-responsenasopharyngeal carcinomasensibilizationtransferrin

Identifiers

PMID31340676
PMCPMC6711081
OpenAlexW2963799473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.