Evidence map›Paper›PMID 31340581›Full record

ArticleInternational journal of molecular sciences2019

Resveratrol Plays a Protective Role against Premature Ovarian Failure and Prompts Female Germline Stem Cell Survival.

Yu Jiang, Zhaoyuan Zhang, Lijun Cha, Lili Li, Dantian Zhu, Zhi Fang, Zhiqiang He, Jian Huang, Zezheng Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu JiangMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Zhaoyuan ZhangFuzhou Medical College of Nanchang University, Nanchang 344000, Jiangxi Province, China.
Lijun ChaMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Lili LiMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Dantian ZhuMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Zhi FangMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Zhiqiang HeMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Jian HuangThe Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Provincial, Nanchang University, Nanchang 330031, Jiangxi Province, China.
Zezheng PanMedical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. panzz@ncu.edu.cn.ORCID 0000-0003-2834-9522
Nanchang University · CN

Funding

National Natural Science Foundation of China 81860263;81660245
6 · The paper itself

Abstract

This study was designed to investigate the protective effect of resveratrol (RES) on premature ovarian failure (POF) and the proliferation of female germline stem cells (FGSCs) at the tissue and cell levels. POF mice were lavaged with RES, and POF ovaries were co-cultured with RES and/or GANT61 in vitro. FGSCs were pretreated with Busulfan and RES and/or GANT61 and co-cultured with M1 macrophages, which were pretreated with RES. The weights of mice and their ovaries, as well as their follicle number, were measured. Ovarian function, antioxidative stress, inflammation, and FGSCs survival were evaluated. RES significantly increased the weights of POF mice and their ovaries as well as the number of follicles, while it decreased the atresia rate of follicles. Higher levels of Mvh, Oct4, SOD2, GPx, and CAT were detected after treatment with RES in vivo and in vitro. RES treatment resulted in significantly lower TNF-α and IL-6 concentrations and an obviously higher IL-10 concentration in the ovaries. In FGSCs, higher Mvh, Oct4, and SOD2 concentrations and lower TNF-α, IL-6, and MDA concentrations were measured in the RES group. Blockage of the Hh signaling pathway reversed the protective effect of RES on FGSCs. In conclusion, RES effectively improved the ovarian function of the POF model and the productive capacity of FGSCs via relieving oxidative stress and inflammation and a mechanism involving the Hh signaling pathway, suggesting that RES is a potential agent against POF and can aid in the survival of FGSCs.

Indexed as

AnimalsAntioxidantsBody WeightBusulfanCatalaseCell SurvivalCoculture TechniquesDEAD-box RNA HelicasesFemaleGene Expression RegulationGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansInterleukin-6MacrophagesMiceAntioxidantsBusulfanCatalaseDdx4 protein, mouseDEAD-box RNA HelicasesGANT 61Glutathione PeroxidaseGlutathione Peroxidase GPX1Interleukin-6interleukin-6, mouseOctamer Transcription Factor-3Pou5f1 protein, mousePyridinesPyrimidinesResveratrolSuperoxide DismutaseSuperoxide Dismutase 2Tumor Necrosis Factor-alphafemale germline stem cellshedgehoginflammationoxidative stresspremature ovarian failureresveratrol

Identifiers

PMID31340581
PMCPMC6678805
OpenAlexW2963668766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.