Evidence map›Paper›PMID 31340478›Full record

ReviewCancers2019

Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes.

Andrea Remo, Matteo Fassan, Alessandro Vanoli, Luca Reggiani Bonetti, Valeria Barresi, Fabiana Tatangelo, Roberta Gafà, Guido Giordano, Massimo Pancione, Federica Grillo and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Colorectal clear cell carcinoma: a literature review.Journal of medical case reports · 2025
    Review
  10. Cancers · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrea RemoPathology Unit, Services Department, ULSS9 "Scaligera", 37122 Verona, Italy. remino76@yahoo.it.ORCID 0000-0002-2564-2988
Matteo FassanDepartment of Medicine (DIMED), Surgical Pathology Unit, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-6515-5482
Alessandro VanoliUnit of Anatomic Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-2976-7032
Luca Reggiani BonettiDepartment of Diagnostic, Clinic and Public Health Medicine, Anatomic Pathology, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Valeria BarresiDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-7086-1920
Fabiana TatangeloDepartment of Pathology, Istituto Nazionale Tumori Fondazione G. Pascale, IRCCS, 80131 Naples, Italy.ORCID 0000-0002-9943-6079
Roberta GafàSection of Anatomic Pathology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara and S. Anna University Hospital, 44121 Ferrara, Italy.
Guido GiordanoU.O.C. Oncologia Medica, Ospedali Riuniti Azienda Ospedaliera Universitaria, 71122 Foggia, Italy.
Massimo PancioneDepartment of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy.
Federica GrilloAnatomic Pathology, Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa and Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Luca MastracciAnatomic Pathology, Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa and Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.

Indexed as

adenocarcinoma with osseous metaplasiaclear cell carcinomacolorectal cancer histotypescribriform/comedo-type carcinomahepatoid carcinomalymphoepitelioma-like carcinomamedullary carcinomamicropapillary carcinomarhabdoid carcinomasignet ring cell carcinoma

Identifiers

PMID31340478
PMCPMC6678907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.