ArticleCell reports2019
Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.Advanced healthcare materials · 2026Article
- Differential synaptic depression mediates the therapeutic effect of deep brain stimulation.Nature neuroscience · 2025Article
- Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease.CNS neuroscience & therapeutics · 2025Review
- Role of HCN channels in the functions of basal ganglia and Parkinson's disease.Cellular and molecular life sciences : CMLS · 2024Review
- Characterization of graded 6-Hydroxydopamine unilateral lesion in medial forebrain bundle of mice.Scientific reports · 2024Article
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes.Journal of neurophysiology · 2023Article
- Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.International journal of molecular sciences · 2023Article
- Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease.Brain communications · 2023Article
- Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions.Acta pharmacologica Sinica · 2022Article
- Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Review
- Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Striatal Direct Pathway Targets Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- ParvalbuminThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Synaptic and cellular plasticity in Parkinson's disease.Acta pharmacologica Sinica · 2020Review
- MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation.Journal of neuroinflammation · 2020Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Abnormal subthalamic nucleus (STN) activity is linked to impaired movement in Parkinson's disease (PD). The autonomous firing of STN neurons, which contributes to their tonic excitation of the extrastriatal basal ganglia and shapes their integration of synaptic input, is downregulated in PD models. Using electrophysiological, chemogenetic, genetic, and optical approaches, we find that chemogenetic activation of indirect pathway striatopallidal neurons downregulates intrinsic STN activity in normal mice but this effect is occluded in Parkinsonian mice. Loss of autonomous spiking in PD mice is prevented by STN N-methyl-D-aspartate receptor (NMDAR) knockdown and reversed by reactive oxygen species breakdown or K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.