Evidence map›Paper›PMID 31340146›Full record

ArticleCell reports2019

Mec1

Gonen Memisoglu, Michael C Lanz, Vinay V Eapen, Jacqueline M Jordan, Kihoon Lee, Marcus B Smolka, James E Haber

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. DNA Damage and Replication Stress Checkpoints.Annual review of biochemistry · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. A DNA damage-induced phosphorylation circuit enhances Mec1Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. DNA damage checkpoint execution and the rules of its disengagement.Frontiers in cell and developmental biology · 2022
    Review
  10. Review
  11. Article
  12. Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).Critical reviews in biochemistry and molecular biology · 2021
    Article
  13. Mechanism of auto-inhibition and activation of Mec1Nature structural & molecular biology · 2021
    Article
  14. Article
  15. Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Checkpoint Responses to DNA Double-Strand Breaks.Annual review of biochemistry · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gonen MemisogluDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA.
Michael C LanzDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Vinay V EapenDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Jacqueline M JordanDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA.
Kihoon LeeDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA; Seegene, Inc., Ogeum-ro, Songpa-gu, Seoul 05548, Korea.
Marcus B SmolkaDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
James E HaberDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA. Electronic address: haber@brandeis.edu.
Brandeis University · USCornell University · USHarvard University · US

Funding

DNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6M
Arrest, Recovery, and Adaptation from DNA DamageR01GM061766 · NIGMS · BRANDEIS UNIVERSITY · PI HABER, JAMES E · 2001 to 2016
$4.6M
Cellular Responses to DNA Replication StressR01GM097272 · NIGMS · CORNELL UNIVERSITY · PI SMOLKA, MARCUS · 2011 to 2020
$2.7M
NIGMS NIH HHS R01 GM061766NIGMS NIH HHS R01 GM097272NIGMS NIH HHS R35 GM127029
6 · The paper itself

Abstract

In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1

Indexed as

DNA DamageSignal TransductionAdaptor Proteins, Signal TransducingAmino Acid SequenceCell Cycle ProteinsDNA Mutational AnalysisDNA RepairIntracellular Signaling Peptides and ProteinsMutationPhosphorylationPhosphoserineProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsIntracellular Signaling Peptides and ProteinsLCD1 protein, S cerevisiaeMEC1 protein, S cerevisiaePhosphoserineProtein Serine-Threonine KinasesSaccharomyces cerevisiae Proteinscell cyclecheckpointDdc2/ATRIPDNA damage responseMec1/ATRPIKKRad53Rad9S. cerevisiae

Identifiers

PMID31340146
PMCPMC7218798
OpenAlexW2962977444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.