Evidence map›Paper›PMID 31340136›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2020

Regulation of mitochondrial quality following repeated bouts of hindlimb unloading.

Megan E Rosa-Caldwell, Jacob L Brown, Richard A Perry, Kevin L Shimkus, Yasaman Shirazi-Fard, Lemuel A Brown, Harry A Hogan, James D Fluckey, Tyrone A Washington, Michael P Wiggs and 1 more

Open access · greenAbstract read
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
  6. Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  7. Review
  8. Mitochondrial Biogenesis in Skeletal Muscle.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Mitochondrial Bioenergetics and Turnover during Chronic Muscle Disuse.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Megan E Rosa-CaldwellIntegrative Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Jacob L BrownIntegrative Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Richard A PerryExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Kevin L ShimkusMuscle Biology Laboratory, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
Yasaman Shirazi-FardBone Biomechanics Laboratory, Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USA.
Lemuel A BrownExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Harry A HoganBone Biomechanics Laboratory, Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USA.
James D FluckeyMuscle Biology Laboratory, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
Tyrone A WashingtonExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Michael P WiggsIntegrated Physiology and Nutrition Laboratory, Department of Health and Kinesiology, University of Texas at Tyler, Tyler, TX 75799, USA.
Nicholas P GreeneIntegrative Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
University of Arkansas at Fayetteville · US

Funding

GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Mitochondrial Degeneration – the Root of Skeletal Muscle AtrophyR15AR069913 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI GREENE, NICHOLAS PERRY · 2017 to 2017
$413k
NIAMS NIH HHS R15 AR069913NIA NIH HHS T32 AG052363
6 · The paper itself

Abstract

Muscle disuse impairs muscle quality and is associated with increased mortality. Little is known regarding additive effects of multiple bouts of disuse, which is a common occurrence in patients experiencing multiple surgeries. Mitochondrial quality is vital to muscle health and quality; however, to date mitochondrial quality control has not been investigated following multiple bouts of disuse. Therefore, the purpose of this study was to investigate mitochondrial quality controllers during multiple bouts of disuse by hindlimb unloading. Male rats (

Indexed as

Organelle BiogenesisAnimalsDisease Models, AnimalHindlimbHindlimb SuspensionMaleMitochondria, MuscleMuscle, SkeletalMuscular AtrophyRatsRats, Sprague-Dawleybed restbiogenèse mitochondrialedisusedynamique mitochondrialeinactivitémitochondrial biogenesismitochondrial dynamicsmitophagiemitophagymusclerepos au lit

Identifiers

PMID31340136
PMCPMC7370318
OpenAlexW2963785847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.