ArticlePloS one2019
Control of neural probe shank flexibility by fluidic pressure in embedded microchannel using PDMS/PI hybrid substrate.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- A Drive-Vibration Integrated Piezoelectric Actuator for Flexible Electrode Implantation.Micromachines · 2026Article
- Systematic evaluation of surgical insertion of flexible neural probe arrays into deeper brain targets using length modulation methods.Journal of neural engineering · 2026Article
- Sampling Probes Microfabricated from Parylene‑C for In Vivo Neurochemical Monitoring.ACS measurement science au · 2025Article
- Intuitive Polydimethylsiloxane Deposition Relying on Resource Conservative, Large Scale Compatible Capillary Flow Dynamics.ACS omega · 2025Article
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Full-field, conformal epiretinal electrode array using hydrogel and polymer hybrid technology.Scientific reports · 2023Article
- Implantable intracortical microelectrodes: reviewing the present with a focus on the future.Microsystems & nanoengineering · 2023Review
- Effects of nanopillars and surface coating on dynamic traction force.Microsystems & nanoengineering · 2023Article
- Fluidic enabled bioelectronic implants: opportunities and challenges.Journal of materials chemistry. B · 2022Review
- Cleanroom strategies for micro- and nano-fabricating flexible implantable neural electronics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Neural microprobe modelling and microfabrication for improved implantation and mechanical failure mitigation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Research Progress on the Flexibility of an Implantable Neural Microelectrode.Micromachines · 2022Review
- Flexible optoelectric neural interfaces.Current opinion in biotechnology · 2021Review
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- A comparison of insertion methods for surgical placement of penetrating neural interfaces.Journal of neural engineering · 2021Review
- Double-Layer Flexible Neural Probe With Closely Spaced Electrodes for High-DensityFrontiers in neuroscience · 2021Article
- Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.Micromachines · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable neural probes are widely used to record and stimulate neural activities. These probes should be stiff enough for insertion. However, it should also be flexible to minimize tissue damage after insertion. Therefore, having dynamic control of the neural probe shank flexibility will be useful. For the first time, we have successfully fabricated flexible neural probes with embedded microfluidic channels for dynamic control of neural probe stiffness by controlling fluidic pressure in the channels. The present hybrid neural probes consisted of polydimethylsiloxane (PDMS) and polyimide (PI) layers could provide the required stiffness for insertion and flexibility during operation. The PDMS channels were fabricated by reversal imprint using a silicon mold and bonded to a PI layer to form the embedded channels in the neural probe. The probe shape was patterned using an oxygen plasma generated by an inductively coupled plasma etching system. The critical buckling force of PDMS/PI neural probes could be tuned from 0.25-1.25 mN depending on the applied fluidic pressure in the microchannels and these probes were successfully inserted into a 0.6% agarose gel that mimicked the stiffness of the brain tissue. Polymer-based neural probes are typically more flexible than conventional metal wire-based probes, and they could potentially provide less tissue damage after implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.