Evidence map›Paper›PMID 31339861›Full record

ArticleAging2019

Genetic polymorphisms and transcription profiles associated with intracranial aneurysm: a key role for NOTCH3.

Mengqi Li, Xinlong Dong, Shi Chen, Weihan Wang, Chao Yang, Bochuan Li, Degang Liang, Weidong Yang, Xiaozhi Liu, Xinyu Yang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Mengqi LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Xinlong DongDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Shi ChenDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Weihan WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Chao YangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Bochuan LiCollaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300052, China.
Degang LiangDepartment of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Weidong YangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Xiaozhi LiuDepartment of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin 300450, China.
Xinyu YangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Tianjin Medical University General Hospital · CNFifth Tianjin Central Hospital · CNTianjin Medical University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial aneurysm (IA) incidence is about 1~2%. However, the specific mechanisms of IA onset and development need further study. Our objective was to discover novel IA-related genes to determine possible etiologies further. We performed next-generation sequencing on nineteen Chinese patients with familial IA and one patient with sporadic IA. We obtained mRNA expression data of 129 samples from Gene Expression Omnibus (GEO) and made statistical computing to discover differentially expressed genes (DEGs). The screened IA-related gene

Indexed as

AdultComputational BiologyFemaleGenetic Predisposition to DiseaseHumansIntracranial AneurysmMaleMiddle AgedPolymorphism, Single NucleotideReceptor, Notch3NOTCH3 protein, humanReceptor, Notch3data miningintracranial aneurysmnext-generation sequencingNOTCH3RNA sequencing

Identifiers

PMID31339861
PMCPMC6682524
OpenAlexW2963997764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.