Evidence map›Paper›PMID 31339663›Full record

ArticleGenes, brain, and behavior2019

Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking.

Yan Zhou, Yupu Liang, Malcolm J Low, Mary J Kreek

Open access · bronzeAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  6. Article
  7. Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yan ZhouLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York.ORCID 0000-0002-5545-5681
Yupu LiangResearch Bioinformatics, CCTS, The Rockefeller University, New York, New York.
Malcolm J LowDepartment of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.
Mary J KreekLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York.
Rockefeller University · USUniversity of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Proopiomelanocortin Gene Expression and ObesityR01DK068400 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 2004 to 2022
$6.6M
Neurochemistry/Physiology of Proopiomelanocortin NeuronsR01DK066604 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 2004 to 2019
$5.2M
Role of hypothalamic-specific POMC deficiency in alcohol reward and drinkingR03AA021970 · NIAAA · ROCKEFELLER UNIVERSITY · PI ZHOU, YAN · 2015 to 2016
$170k
NIAAA NIH HHS NIH AA021970NIAAA NIH HHS R03 AA021970NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK066604NIDDK NIH HHS R01 DK068400
6 · The paper itself

Abstract

Persistent alterations of proopiomelanocortin (Pomc) and mu-opioid receptor (Oprm1) activity and stress responses after alcohol are critically involved in vulnerability to alcohol dependency. Gene transcriptional regulation altered by alcohol may play important roles. Mice with genome-wide deletion of neuronal Pomc enhancer1 (nPE1

Indexed as

AnimalsArginine VasopressinBinge DrinkingEnhancer Elements, GeneticEnkephalinsEthanolHypothalamusMaleMiceMice, Inbred C57BLOxytocinPro-OpiomelanocortinProtein PrecursorsReceptors, Opioid, muTranscriptomeArginine VasopressinEnkephalinsEthanolOxytocinpreproenkephalinPro-OpiomelanocortinProtein PrecursorsReceptors, Opioid, mualcoholnPE1 knockoutnuclear transcriptopioidRNA-Seqstress

Identifiers

PMID31339663
PMCPMC7112180
OpenAlexW2963669589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.