Evidence map›Paper›PMID 31339489›Full record

ArticleeLife2019

Characterizing functional pathways of the human olfactory system.

Guangyu Zhou, Gregory Lane, Shiloh L Cooper, Thorsten Kahnt, Christina Zelano

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Olfactory Testing in Temporal Lobe Epilepsy: a Systematic Review.Current neurology and neuroscience reports · 2020
    Pooled it
  2. Article
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  19. IMPAIRED OLFACTORY FUNCTION IN SUBSTANCE USE DISORDER.medRxiv : the preprint server for health sciences · 2025
    Article
  20. Olfactory network reorganization in Parkinson's disease.Parkinsonism & related disorders · 2025
    Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangyu ZhouDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0003-0897-6465
Gregory LaneDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0003-3101-0722
Shiloh L CooperDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-0801-6352
Thorsten KahntDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.ORCID 0000-0002-3575-2670
Christina ZelanoDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.

Funding

PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Principles of olfactory reward processing in the human brainR01DC015426 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZELANO, CHRISTINA MARIA · 2016 to 2025
$4.4M
The function of respiratory-linked local field potential oscillations in human olfactory and limbic brain regionsR01DC016364 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZELANO, CHRISTINA MARIA · 2018 to 2022
$2.1M
Attention-dependent neural oscillations in the human olfactory systemR00DC012803 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZELANO, CHRISTINA MARIA · 2015 to 2017
$732k
NIA NIH HHS T32 AG020506NIDCD NIH HHS R00-DC-0012803NIDCD NIH HHS R00 DC012803NIDCD NIH HHS R01 DC015426NIDCD NIH HHS R01-DC-015426NIDCD NIH HHS R01 DC016364NIDCD NIH HHS R01-DC-016364
6 · The paper itself

Abstract

The central processing pathways of the human olfactory system are not fully understood. The olfactory bulb projects directly to a number of cortical brain structures, but the distinct networks formed by projections from each of these structures to the rest of the brain have not been well-defined. Here, we used functional magnetic resonance imaging and k-means clustering to parcellate human primary olfactory cortex into clusters based on whole-brain functional connectivity patterns. Resulting clusters accurately corresponded to anterior olfactory nucleus, olfactory tubercle, and frontal and temporal piriform cortices, suggesting dissociable whole-brain networks formed by the subregions of primary olfactory cortex. This result was replicated in an independent data set. We then characterized the unique functional connectivity profiles of each subregion, producing a map of the large-scale processing pathways of the human olfactory system. These results provide insight into the functional and anatomical organization of the human olfactory system.

Indexed as

AdultAnatomy, ArtisticAtlases as TopicFemaleHumansMaleNerve NetOlfactory CortexOlfactory Pathwayscomputational biologyfunctional connectivityhumanneuroscienceolfactionprimary olfactory cortexsystems biology

Identifiers

PMID31339489
PMCPMC6656430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.