Evidence map›Paper›PMID 31339476›Full record

ArticleInternational journal of circumpolar health2019

Environmental chemical exposures among Greenlandic children in relation to diet and residence.

Clara Amalie Gade Timmermann, Henning Sloth Pedersen, Esben Budtz-Jørgensen, Peter Bjerregaard, Youssef Oulhote, Pál Weihe, Flemming Nielsen, Philippe Grandjean

Abstract read
In one paragraph

Article in International journal of circumpolar health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  4. Review
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  6. Article
  7. Review
  8. Levels and trends of metals in human populations living in the Arctic.International journal of circumpolar health · 2024
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clara Amalie Gade Timmermanna Department of Environmental Medicine, University of Southern Denmark , Odense C , Denmark.ORCID 0000-0001-9847-2038
Henning Sloth Pedersena Department of Environmental Medicine, University of Southern Denmark , Odense C , Denmark.ORCID 0000-0002-9194-4423
Esben Budtz-Jørgensenc Section of Biostatistics, University of Copenhagen , Copenhagen K , Denmark.ORCID 0000-0002-5551-0724
Peter Bjerregaardb Greenland Centre for Health Research, University of Greenland , Nuuk , Greenland.ORCID 0000-0001-7153-8447
Youssef Oulhotee Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston , MA , USA.ORCID 0000-0002-2323-1982
Pál Weihef Department of Occupational Medicine and Public Health, The Faroese Hospital System , Tórshavn , Faroe Islands.ORCID 0000-0001-8174-3671
Flemming Nielsena Department of Environmental Medicine, University of Southern Denmark , Odense C , Denmark.ORCID 0000-0002-5657-405X
Philippe Grandjeana Department of Environmental Medicine, University of Southern Denmark , Odense C , Denmark.ORCID 0000-0003-4046-9658

Funding

Gut Microbiome in Adults with Early Life Exposures to Environmental ChemicalsR21ES023376 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRANDJEAN, PHILIPPE ADAM · 2014 to 2016
$864k
Immunotoxicity in Humans with Lifetime Exposure to Ocean PullutantsR01ES021993 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRANDJEAN, PHILIPPE ADAM · 2012 to 2016
$762k
NIEHS NIH HHS R01 ES021993NIEHS NIH HHS R21 ES023376
6 · The paper itself

Abstract

The objective of this study was to identify geographic, dietary, and other predictors for childhood exposure to perfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and methylmercury in Greenlandic children. The study includes cross-sectional data from 367 Greenlandic children aged 7 to 12 years examined during 2012-2015. A parent or guardian participated in a structured interview, and a blood sample from the child was analysed for PFASs, PCBs and total mercury. Predictors for the environmental exposures were identified using linear regression. Area of residence was found to have the strongest explanatory power, accounting for 24% to 68% of the variance in the serum concentrations. Information about diet was available for two-thirds of the children, and among these, consumption of traditional Greenlandic food accounted for 2% to 10% of the variance in the biomarker concentrations. Models including all predictors associated with at least one of the environmental chemicals explained 19% to 54% of the total variance. In conclusion, area is a likely proxy for a traditional marine diet, and together area and diet constitute the most important predictors of exposure to methylmercury, PCBs and PFASs among Greenlandic children.

Indexed as

ChildDietEnvironmental ExposureEnvironmental PollutantsFemaleFluorocarbonsGeographyGreenlandHumansMaleMethylmercury CompoundsPolychlorinated BiphenylsEnvironmental PollutantsFluorocarbonsMethylmercury CompoundsPolychlorinated BiphenylsContaminantsdietGreenlandmercuryperfluoroalkyl substance (PFAS)polychlorinated biphenyl (PCB)predictors

Identifiers

PMID31339476
PMCPMC6711189

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.