Evidence map›Paper›PMID 31339428›Full record

ArticleAutophagy2019

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy.

Tatsuya Yamada, Ted M Dawson, Toru Yanagawa, Miho Iijima, Hiromi Sesaki

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Mitophagy coordinates organelle crosstalk in health and diseases.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  17. Review
  18. Review
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tatsuya YamadaDepartment of Cell Biology, Johns Hopkins University School of Medicine , Baltimore , MD , USA.ORCID 0000-0002-6906-9861
Ted M DawsonDepartments of Neurology and Neuroscience, Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Toru YanagawaDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba , Ibaraki , Japan.ORCID 0000-0003-0868-2563
Miho IijimaDepartment of Cell Biology, Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Johns Hopkins University · USUniversity of Tsukuba · JP

Funding

Regulation of Intracellular SignalingR35GM131768 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Miho Iijima · 2019 to 2026
$4.0M
Lipid Signaling in ChemotaxisR01GM084015 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IIJIMA, MIHO · 2009 to 2019
$2.9M
Mitochondrial Quality Control by Drp1R01GM123266 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2018 to 2021
$1.4M
Regulation of Mitochondrial Division by Phosphatidic AcidR01GM130695 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2019 to 2021
$933k
NIGMS NIH HHS R01 GM084015NIGMS NIH HHS R01 GM123266NIGMS NIH HHS R01 GM130695NIGMS NIH HHS R35 GM131768
6 · The paper itself

Abstract

The ubiquitination of mitochondrial proteins labels damaged mitochondria for degradation through mitophagy. We recently developed an

Indexed as

AnimalsDynaminsGTP PhosphohydrolasesHepatocytesMiceMitochondriaMitochondrial DynamicsMitophagyProtein KinasesPTEN-Induced Putative KinaseSequestosome-1 ProteinUbiquitinationUbiquitin-Protein LigasesDnm1l protein, mouseDynaminsGTP PhosphohydrolasesMfn1 protein, mouseMfn2 protein, mouseparkin proteinProtein KinasesPTEN-Induced Putative KinaseSequestosome-1 ProteinSqstm1 protein, mouseUbiquitin-Protein LigasesDnm1l/Drp1mitochondriamitochondrial divisionmitophagyPINK1PRKN/parkin

Identifiers

PMID31339428
PMCPMC6844492
OpenAlexW2963741701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.