Evidence map›Paper›PMID 31339057›Full record

ArticleJournal of the American Heart Association2019

Th2 CD4

Rahul Kumar, Claudia Mickael, Biruk Kassa, Linda Sanders, Dan Koyanagi, Daniel Hernandez-Saavedra, Scott Freeman, Daniel Morales-Cano, Angel Cogolludo, Amy S McKee and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Pulmonary Immune Cell Landscape Altered by Exposure to HIV,International journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Intrapulmonary T Cells Are Sufficient forInternational journal of molecular sciences · 2024
    Article
  10. Interstitial macrophage phenotypes inFrontiers in immunology · 2024
    Article
  11. ExperimentalPulmonary circulation · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Rahul KumarDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Claudia MickaelDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Biruk KassaDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Linda SandersDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Dan KoyanagiDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Daniel Hernandez-SaavedraDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Scott FreemanDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Daniel Morales-CanoDepartment of Pharmacology and Toxicology School of Medicine University Complutense of Madrid Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM) Madrid Spain.
Angel CogolludoDepartment of Pharmacology and Toxicology School of Medicine University Complutense of Madrid Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM) Madrid Spain.
Amy S McKeeDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Andrew P FontenotDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Ghazwan ButrousPharmaceutical Sciences University of Kent Canterbury United Kingdom.
Rubin M TuderDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Brian B GrahamDepartment of Medicine University of Colorado Anschutz Medical Campus Aurora CO.
University of Colorado Anschutz Medical Campus · USCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESUniversity of Kent · GB

Funding

VRAC and Rho in pulmonary EC proliferationP01HL014985 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1985 to 2019
$35.1M
Translational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
Interactions between antigen-specific effector and regulatory T cells in beryllium-induced diseaseR01ES025534 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 2016 to 2020
$2.1M
Innate effects of beryllium on pulmonarydendritic cell function in chronic beryllium diseaseR01HL126736 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKEE, AMY STRAW · 2016 to 2020
$1.9M
Role of Th2 CD4 T Cells in Schistosoma Pulmonary HypertensionR03HL133306 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GRAHAM, BRIAN BARKLEY · 2016 to 2017
$156k
NHLBI NIH HHS P01 HL014985NHLBI NIH HHS R01 HL126736NHLBI NIH HHS R01 HL135872NHLBI NIH HHS R03 HL133306NHLBI NIH HHS T32 HL007171NIAID NIH HHS HHSN272201000005CNIAID NIH HHS HHSN272201000005INIEHS NIH HHS R01 ES025534
6 · The paper itself

Abstract

Background Inflammation underlies many forms of pulmonary hypertension (PH), including that resulting from Schistosoma infection, a major cause of PH worldwide. Schistosomiasis-associated PH is proximately triggered by embolization of parasite eggs into the lungs, resulting in localized type 2 inflammation. However, the role of CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleHypertension, PulmonaryMiceMice, Inbred C57BLPneumoniaSchistosomiasisTh2 CellsCD4 T cellpulmonary hypertensionschistosomiasistype 2 immunity

Identifiers

PMID31339057
PMCPMC6761627
OpenAlexW2963121806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.