Evidence map›Paper›PMID 31338672›Full record

ArticlePurinergic signalling2019

Inhibition of vascular smooth muscle cell calcification by ATP analogues.

Jessal J Patel, Lucie E Bourne, José Luis Millán, Timothy R Arnett, Vicky E MacRae, Caroline P D Wheeler-Jones, Isabel R Orriss

Open access · hybridAbstract read
In one paragraph

Article in Purinergic signalling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jessal J PatelDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK.
Lucie E BourneDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK.
José Luis MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
Timothy R ArnettDepartment of Cell and Developmental Biology, University College London, London, UK.
Vicky E MacRaeThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
Caroline P D Wheeler-JonesDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK.
Isabel R OrrissDepartment of Comparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK. iorriss@rvc.ac.uk.ORCID 0000-0002-7847-050X
Royal Veterinary College · GBRoslin Institute · GBSanford Burnham Prebys Medical Discovery Institute · USUniversity College London · GB

Funding

MOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2M
Biotechnology and Biological Sciences Research Council BB/J004316/1 and BB/P013732/1British Heart Foundation PG/15/13/31296NIDCR NIH HHS R01 DE012889
6 · The paper itself

Abstract

Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous work has shown that ATP/UTP can inhibit AMC directly via P2 receptors and indirectly by NPP1-mediated hydrolysis to produce the mineralisation inhibitor, pyrophosphate (PP

Indexed as

Adenosine TriphosphateAnimalsCalcinosisMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MusclePhosphoric Diester HydrolasesPyrophosphatasesReceptors, Purinergic P2Adenosine Triphosphateectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatasesReceptors, Purinergic P2Arterial medial calcificationATP analoguesP2X receptorsVascular smooth muscle cells

Identifiers

PMID31338672
PMCPMC6737162
OpenAlexW2968802936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.