Evidence map›Paper›PMID 31338587›Full record

ArticleVirchows Archiv : an international journal of pathology2019

Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.

Chiara Saglietti, Vanessa Schneider, Massimo Bongiovanni, Edoardo Missiaglia, Bettina Bisig, Gian Dorta, Nicolas Demartines, Christine Sempoux, Stefano La Rosa

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chiara SagliettiInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Vanessa SchneiderInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Massimo BongiovanniInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Edoardo MissiagliaInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Bettina BisigInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Gian DortaDepartment of Gastroenterology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nicolas DemartinesDepartment of Visceral Surgery, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Christine SempouxInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Stefano La RosaInstitute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. stefano.larosa@chuv.ch.ORCID http://orcid.org/0000-0003-1941-2403
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have recently been described and include oncocytic, spindle, clear, and pleomorphic cell types. This wide histological spectrum represents a challenge in the diagnostic task for pathologists. Molecular mechanisms involved in the onset and progression of ACCs are not completely known, but, in general, they differ from those observed in ductal adenocarcinomas or neuroendocrine neoplasms of the pancreas and frequently include alterations in the APC/β-catenin pathway. In the present paper, we describe a new variant of ACC showing thyroid-like follicular features and CTNNB1 mutation. This phenotype needs to be included in the spectrum of morphological presentation of ACC.

Indexed as

beta CateninCarcinoma, Acinar CellDiagnosis, DifferentialHumansMaleMiddle AgedMutationPancreatic NeoplasmsThyroid Glandbeta CateninCTNNB1 protein, humanAcinar cell carcinomaDifferential diagnosisMorphologyPancreasThyroid-like

Identifiers

PMID31338587
OpenAlexW2964328895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.