Evidence map›Paper›PMID 31338559›Full record

ReviewPediatric cardiology2019

Partially Penetrant Cardiac Neural Crest Defects in Hand1 Phosphomutant Mice: Dimer Choice That Is Not So Critical.

Beth A Firulli, Anthony B Firulli

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Beth A FirulliHerman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA.
Anthony B FirulliHerman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA. tfirulli@iu.edu.ORCID http://orcid.org/0000-0001-6687-8949
Indiana University School of Medicine

Funding

Transcriptional regulation of cardiac morphogenesisP01HL134599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Lei Yang · 2017 to 2026
$25.7M
Transcriptional regulation of cardiac conduction system morphogenesisR01HL145060 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIRULLI, ANTHONY B., SHOU, WEINIAN · 2019 to 2022
$2.8M
Cellular and Molecular Mechanisms of Left Ventricular Growth and MorphogenesisR01HL122123 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIRULLI, ANTHONY B. · 2014 to 2017
$1.6M
NHLBI NIH HHS 1R01HL122123-04NHLBI NIH HHS P01 HL134599NHLBI NIH HHS P01HL134599NHLBI NIH HHS R01 HL122123NHLBI NIH HHS R01 HL145060
6 · The paper itself

Abstract

Hand1 is a basic Helix-loop-Helix transcription factor that exhibits post-translationally regulated dimer partner choice that allows for a diverse set of Hand1 transcriptional complexes. Indeed, when Hand1 phosphoregulation is altered, conditionally activated hypophorylation (Hand1

Indexed as

AllelesAnimalsBasic Helix-Loop-Helix ProteinsDouble Outlet Right VentricleGene Expression Regulation, DevelopmentalHumansMiceMorphogenesisNeural CrestPhenotypeTranscription, GeneticBasic Helix-Loop-Helix ProteinsHand1 protein, mousebHLHDimer regulationHand1Post-translational modifications

Identifiers

PMID31338559
PMCPMC6786956
OpenAlexW2964767158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.