Evidence map›Paper›PMID 31338545›Full record

Trial reportDiabetologia2019

A carbohydrate-reduced high-protein diet improves HbA

Mads J Skytte, Amirsalar Samkani, Amy D Petersen, Mads N Thomsen, Arne Astrup, Elizaveta Chabanova, Jan Frystyk, Jens J Holst, Henrik S Thomsen, Sten Madsbad and 3 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 10 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02764021 nacompletednot on this map

Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes; Mechanisms of Effective Therapy of Diabetes by Selective Choice of Macronutrients. The Isoenergetic Study.

TypeinterventionalSponsorBispebjerg HospitalRan2016 to 2017Enrolled32ConditionsType 2 Diabetes MellitusArmsCarbohydrate-Restricted Diet, Standard Antidiabetic Diet
NCT07632222 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of a High-Protein Diet Versus a Standard Diet in Patients With Alcoholic Fatty Liver Disease: A Randomized Controlled Trial

TypeinterventionalSponsorLi Lab,MDRan2026 to 2027Enrolled74ConditionsAlcohol-associated Fatty Liver DiseaseArmshigh protein diet, control diet, perilla peptide dietary group
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 10 syntheses or guidelines pooled it, 154 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Mads J SkytteDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark. mads.gustav.juul.skytte@regionh.dk.
Amirsalar SamkaniDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Amy D PetersenDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Mads N ThomsenDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Arne AstrupDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Elizaveta ChabanovaDepartment of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
Jan FrystykDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Jens J HolstNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Henrik S ThomsenDepartment of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark.
Sten MadsbadDepartment of Endocrinology, Copenhagen University Hospital Amager Hvidovre, Copenhagen, Denmark.
Thomas M LarsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Steen B HaugaardDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Thure KrarupDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.
Bispebjerg Hospital · DKUniversity of Copenhagen · DKAmager Hospital · DKHerlev Hospital · DKAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisDietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in carbohydrate content is acknowledged. We compared a carbohydrate-reduced high-protein (CRHP) diet with an iso-energetic conventional diabetes (CD) diet to elucidate the effects on glycaemic control and selected cardiovascular risk markers during 6 weeks of full food provision of each diet.

methodsThe primary outcome of the study was change in HbA

resultsTwenty-eight participants completed the study. Fourteen participants carried out 6 weeks of the CRHP intervention followed by 6 weeks of the CD intervention, and 14 participants received the dietary interventions in the reverse order. Compared with a CD diet, a CRHP diet reduced the primary outcome of HbA CONCLUSIONS/

interpretationA moderate macronutrient shift by substituting carbohydrates with protein and fat for 6 weeks reduced HbA

trial registrationClinicalTrials.gov NCT02764021.

fundingThe study was funded by grants from Arla Food for Health; the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen; the Department of Clinical Medicine, Aarhus University; the Department of Nutrition, Exercise and Sports, University of Copenhagen; and Copenhagen University Hospital, Bispebjerg.

Indexed as

Diet, Carbohydrate-RestrictedDiet, High-ProteinAdipose TissueAgedAnthropometryBlood GlucoseBlood PressureBody WeightCardiovascular DiseasesCross-Over StudiesDiabetes Mellitus, Type 2Fatty LiverFemaleGlycated HemoglobinHumansLiverBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanCarbohydrate restrictionCardiovascular diseaseDietary interventionEctopic fat depositionGlycaemic controlMetabolismNon-alcoholic fatty liver diseaseNutritional therapyType 2 diabetes mellitusWeight stability

Identifiers

PMID31338545
OpenAlexW2963081635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.