ReviewHeliyon2019
Application of cell-sheet engineering for new formation of cementum around dental implants.
Review in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Buccal fat pad graft for the closure of the oroantral fistula following dental implant removal.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/TiACS applied materials & interfaces · 2025Article
- Simultaneous Osseo- and Odontointegration of Titanium Implants: Description of Two Cases in Human and Animal Models and Review of Their Experimental and Clinical Implications.Materials (Basel, Switzerland) · 2024Article
- Infrared diode laser enhances human periodontal ligament stem cells behaviour on titanium dental implants.Scientific reports · 2024Article
- Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges-A Narrative Review.Scientifica · 2024Review
- Review
- Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects.Stem cell research & therapy · 2023Review
- Isolation and characterization of apical papilla cells from root end of human third molar and their differentiation into cementoblast cells: an in vitro study.Biological procedures online · 2023Article
- Bio-hybrid dental implants prepared using stem cells with β-TCP-coated titanium and zirconia.Journal of periodontal & implant science · 2022Article
- A Review of In Vivo and Clinical Studies Applying Scaffolds and Cell Sheet Technology for Periodontal Ligament Regeneration.Biomolecules · 2022Review
- Bioinformatics Analysis Identified miR-584-5p and Key miRNA-mRNA Networks Involved in the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.Frontiers in genetics · 2021Article
- Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments.Frontiers in bioengineering and biotechnology · 2021Review
- Characteristics, Classification, and Application of Stem Cells Derived from Human Teeth.Stem cells international · 2021Review
- Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies.Molecules (Basel, Switzerland) · 2020Review
- Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020Review
- Biomimetic Properties of Engineered Periodontal Ligament/Cementum in Dental Implants.Contemporary clinical dentistryReview
- Innovations in Dental Implants Integration: Optimizing dental implants performance utilizing stem cells and coatings.Biotechnology progressReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease involves the chronic inflammation of tooth supporting periodontal tissues. As the disease progresses, it manifests destruction of periodontal tissues and eventual tooth loss. The regeneration of lost periodontal tissue has been one of the most important subjects in periodontal research. Since their discovery, periodontal ligament stem cells (PDLSCs), have been transplanted into periodontal bony defects to examine their regenerative potential. Periodontal defects were successfully regenerated using PDLSC sheets, which were fabricated by cell sheet engineering in animal models, and for which clinical human trials are underway. To expand the utility of PDLSC sheet, we attempted to construct periodontal tissues around titanium implants with the goal of facilitating the prevention of peri-implantitis. In so doing, we found newly formed cementum-periodontal ligament (PDL) structures on the implant surface. In this mini review, we summarize the literature regarding cell-based periodontal regeneration using PDLSCs, as well as previous trials aimed at forming periodontal tissues around dental implants. Moreover, the recent findings in cementogenesis are reviewed from the perspective of the formation of further stable periodontal attachment structure on dental implant. This mini review aims to summarize the current status of the creation of novel periodontal tissue-bearing dental implants, and to consider its future direction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.