Evidence map›Paper›PMID 31338449›Full record

ArticleHeliyon2019

CFC delta-beta is related with mixed features and response to treatment in bipolar II depression.

S Kesebir, R M Demirer, N Tarhan

Erratum issuedAbstract read
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

S KesebirÜsküdar University, NPİstanbul Brain Hospital, İstanbul, Turkey.
R M DemirerÜsküdar University, Biomedical Engineering, İstanbul, Turkey.
N TarhanÜsküdar University, NPİstanbul Brain Hospital, İstanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate whether differentiation of delta-beta cross frequency coupling (CFC) in bipolar II depressive episode with mixed features and consecutive remission was observed.

methods8 patient diagnosed bipolar disorder type II, depressive episode with mixed features according to DSM-V, were examined during the current episode, at baseline and end of the third week of lamotrigine use. Hamilton Depression Rating Scale (HDRS) and Mood Disorder Questionnaire (MDQ) were applied to each case at the baseline and end of the third week and QEEG was performed. Temperament was evaluated with TEMPS-A.

resultsdPAC-DB and AAC-DB were significantly higher in FP2 at the end of 3rd weeks of lamotrigine use. A linear relationship was found between F3 dPAC-DB and MDQ scores, before and after treatment. P3 dPAC-DB was correlated with HDRS scores initially only. Cyclothymic temperament scores was found related with dPAC-DB and AAC-DB in F4.

conclusionIn bipolar disorder, delta-beta CFC was first investigated in this study. CFCs may have a neural projection of the physiopathology of bipolar disorder. At the point we reached in this study, we can show it as both state and trait.

Indexed as

Bipolar depressionCross frequency couplingMixed featuresNeuroscienceQEEGTreatment response to lamotrigine

Identifiers

PMID31338449
PMCPMC6580232

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.