ArticleJournal of dental anesthesia and pain medicine2019
Painless injections-a possibility with low level laser therapy.
Article in Journal of dental anesthesia and pain medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07288125 (The Effect of Cold Atmospheric Plasma on Patient Comfort During Dental Infiltration Anesthesia), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Cold Atmospheric Plasma on Patient Comfort During Dental Infiltration Anesthesia: A Randomized Controlled Split-Mouth Clinical Trial
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The role of photobiomodulation in minimizing pain during dental injections in adults and children: a systematic review and meta-analysis.Lasers in medical science · 2025Pooled it
- Effect of photobiomodulation therapy on pain perception during anesthetic puncture of dental local anesthesia: A systematic review.Clinics (Sao Paulo, Brazil) · 2024Pooled it
- Evaluation of the efficacy of photobiomodulation for the reduction of dental injection pain: a split-mouth placebo-controlled randomized controlled trial.Lasers in medical science · 2025Trial
- The use of laser photobiomodulation as pre-anesthetic tissue management technique in reducing injection pain in children.BMC oral health · 2024Trial
- The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Evaluation of the effects of photobiomodulation with different laser application doses on injection pain in children: a randomized clinical trial.Lasers in medical science · 2022Trial
- Effect of low-level laser therapy on pain perception and anxiety levels in conventional local anesthesia injection.Journal of dental anesthesia and pain medicine · 2025Article
- Effect of photo-bio-modulation on pain perception with inferior alveolar nerve block among children: A split mouth study.Bioinformation · 2025Article
- The efficacy of photobiomodulation on dental injection pain: a systematic review of randomized clinical trials.Journal of dental anesthesia and pain medicine · 2024Review
- Low-level Laser Therapy to Alleviate Pain of Local Anesthesia Injection in Children: A Randomized Control Trial.International journal of clinical pediatric dentistry · 2023Article
- Effect of Photobiomodulation Therapy With an 810-nm Diode Laser on Pain Perception Associated With Dental Injections in Children: A Double-Blind Randomized Controlled Clinical Trial.Journal of lasers in medical sciences · 2023Article
- Does a New Modification of the Two-Step Injection Technique for Inferior Alveolar Nerve Block Reduce Pain Compared to the Conventional Technique? A Randomized Clinical Trial.International journal of dentistry · 2023Article
- DentalVibe reduces pain during the administration of local anesthetic injection in comparison to 2% lignocaine gel: results from a clinical study.Journal of dental anesthesia and pain medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDental procedures commonly involve the injection of local anesthetic agents, which causes apprehension in patients. The objective of dental practice is to provide painless treatment to the patient. The purpose of this study was to evaluate the effect of Low Level Laser Therapy (LLLT) in reducing the pain due to local anesthetic injection. MATERIALS AND
methodsA prospective, split-mouth study was conducted on 25 patients. In Condition A, LLLT was administered followed by the administration of a standard local anesthetic agent. Patients' perception of pain with use of LLLT was assessed based on a Visual Analogue Scale (VAS). In Condition B, LLLT was directed to the mucosa but not activated, followed by the administration of local anesthesia. VAS was used to assess the pain level without the use of LLLT.
resultsComparison between Condition A and Condition B was done. A P value < 0.001 was considered significant, indicating a definite statistical difference between the two conditions.
conclusionIn our study, we observed that LLLT reduced pain during injection of local anesthesia. Further multi-centric studies with a larger sample size and various modifications in the study design are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.