ArticleAnatomy & cell biology2019
Vitamin C restores ovarian follicular reservation in a mouse model of aging.
Article in Anatomy & cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Slowing down the clock on ovarian aging-does the ovary hold the secret to the fountain of youth?GeroScience · 2026Review
- Effects of quercetin supplementation in aging mice on oocyte number, in vitro fertilization and embryo development outcomes.JBRA assisted reproduction · 2026Article
- The importance of ovary-immune interactions in the context of age and disease.Frontiers in neuroendocrinology · 2026Review
- Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging.Journal of ovarian research · 2025Article
- Effect of dietary patterns and nutritional supplementation in the management of endometriosis: a review.Frontiers in nutrition · 2025Review
- Metabolomic Analysis of Histological Composition Variability of High-Grade Serous Ovarian Cancer UsingInternational journal of molecular sciences · 2024Article
- Vitamin C Improves Oocyte In Vitro Maturation and Potentially Changes Embryo Quality in Cattle.Veterinary sciences · 2024Article
- Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells.Antioxidants (Basel, Switzerland) · 2024Article
- The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency.Antioxidants (Basel, Switzerland) · 2023Review
- The Importance of Natural Antioxidants in Female Reproduction.Antioxidants (Basel, Switzerland) · 2023Review
- Prenatal exposure to acrylamide differently affected the sex ratio, aromatase and apoptosis in female adult offspring of two subsequent generations.Physiological research · 2023Article
- Mitochondria in reproduction.Clinical and experimental reproductive medicine · 2023Article
- Current progress onFrontiers in cell and developmental biology · 2023Review
- Unraveling female reproductive senescence to enhance healthy longevity.Cell research · 2023Review
- Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.Cell proliferation · 2022Article
- Natural Compounds and Products from an Anti-Aging Perspective.Molecules (Basel, Switzerland) · 2022Review
- Lower Plasmatic Levels of Saturated Fatty Acids and a Characteristic Fatty Acid Composition in the Ovary Could Contribute to the High-Fertility Phenotype in Dummerstorf Superfertile Mice.International journal of molecular sciences · 2022Article
- The role of oxidative stress in ovarian aging: a review.Journal of ovarian research · 2022Review
- Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin.Journal of ovarian research · 2021Article
- Mapping of folic acid in the children brainstem.Anatomy & cell biology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian aging is related to the reduction of oocyte quality and ovarian follicles reservation leading to infertility. Vitamin C is a natural antioxidant which may counteract with adverse effects of aging in the ovary. The aim of this study was to evaluate the possible effect of vitamin C on NMRI mice ovarian aging according to the stereological study. In this experimental study, 36 adult female mice (25-30 g) were divided into two groups: control and vitamin C. Vitamin C (150 mg/kg/day) were administered by oral gavage for 33 weeks. Six animals of each group were sacrificed on week 8, 12, and 33, and right ovary samples were extracted for stereology analysis. Our data showed that the total volume of ovary, cortex, medulla and corpus luteum were significantly increased in vitamin C group in comparison to the control groups (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.