ReviewSpinal cord2019
Application of electrophysiological measures in spinal cord injury clinical trials: a narrative review.
Review in Spinal cord, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury.Frontiers in cellular neuroscience · 2022Pooled it
- Methodological optimization for eliciting robust median nerve somatosensory evoked potentials for realtime single trial applications.Journal of neural engineering · 2026Article
- The role of surface EMG in predicting responsiveness of muscles to FES therapy after cervical SCI.Journal of neuroengineering and rehabilitation · 2025Article
- Correlation between neurogenic injury and lumbar disc degeneration in tethered cord syndrome: a retrospective MRI study based on somatosensory evoked potentials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Detection of spinal action potentials with subdural electrodes in freely moving rodents.Scientific reports · 2025Article
- Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross-sectional MRI study.Annals of clinical and translational neurology · 2025Article
- Exploring the Landscape of Biomarkers in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025Review
- Dynamic Epidural Monitoring of Spinal Cord Neural Conduction Using a Novel Implantable Electrodiagnostic Sensor: A Pre Clinical Study.Neurotrauma reports · 2025Article
- Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury.Stem cell research & therapy · 2024Review
- Electrophysiology Methods for Assessing of Neurodegenerative and Post-Traumatic Processes as Applied to Translational Research.Life (Basel, Switzerland) · 2024Review
- Prediction of early bladder outcomes after spinal cord injury: The HALT score.CNS neuroscience & therapeutics · 2024Article
- Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression.Scientific reports · 2023Article
- Functional electrical stimulation therapy for upper extremity rehabilitation following spinal cord injury: a pilot study.Spinal cord series and cases · 2023Article
- Clinical Utility of Diffusion Tensor Imaging as a Biomarker to Identify Microstructural Changes in Pediatric Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2022Article
- Utility of transcranial magnetic stimulation in the assessment of spinal cord injury: Current status and future directions.Frontiers in rehabilitation sciences · 2022Review
- Article
- Properties of the surface electromyogram following traumatic spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2021Article
- Assessment of neuropathic pain after spinal cord injury using quantitative pain drawings.Spinal cord · 2021Article
- Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury.Experimental brain research · 2021Article
- Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system.Spinal cord · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designNarrative review.
objectivesTo discuss how electrophysiology may contribute to future clinical trials in spinal cord injury (SCI) in terms of: (1) improvement of SCI diagnosis, patient stratification and determination of exclusion criteria; (2) the assessment of adverse events; and (3) detection of therapeutic effects following an intervention.
methodsAn international expert panel for electrophysiological measures in SCI searched and discussed the literature focused on the topic.
resultsElectrophysiology represents a valid method to detect, track, and quantify readouts of nerve functions including signal conduction, e.g., evoked potentials testing long spinal tracts, and neural processing, e.g., reflex testing. Furthermore, electrophysiological measures can predict functional outcomes and thereby guide rehabilitation programs and therapeutic interventions for clinical studies.
conclusionObjective and quantitative measures of sensory, motor, and autonomic function based on electrophysiological techniques are promising tools to inform and improve future SCI trials. Complementing clinical outcome measures, electrophysiological recordings can improve the SCI diagnosis and patient stratification, as well as the detection of both beneficial and adverse events. Specifically composed electrophysiological measures can be used to characterize the topography and completeness of SCI and reveal neuronal integrity below the lesion, a prerequisite for the success of any interventional trial. Further validation of electrophysiological tools with regard to their validity, reliability, and sensitivity are needed in order to become routinely applied in clinical SCI trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.