ArticleScientific reports2019
Precursors of seizures due to specific spatial-temporal modifications of evolving large-scale epileptic brain networks.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy.Scientific reports · 2021Trial
- Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities.Scientific reports · 2020Trial
- Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Preictal connectivity dynamics: Exploring inflow and outflow in iEEG networks.Frontiers in network physiology · 2025Article
- EEG epilepsy seizure prediction: the post-processing stage as a chronology.Scientific reports · 2024Article
- Seizure forecasting: Where do we stand?Epilepsia · 2023Article
- Impact of biological rhythms on the importance hierarchy of constituents in time-dependent functional brain networks.Frontiers in network physiology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness.Scientific reports · 2022Article
- Sequential Semiology of Seizures and Brain Perfusion Patterns in Patients with Drug-Resistant Focal Epilepsies: A Perspective from Neural Networks.Behavioral sciences (Basel, Switzerland) · 2022Article
- A straightforward edge centrality concept derived from generalizing degree and strength.Scientific reports · 2022Article
- Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy.Brain communications · 2022Article
- Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner.Frontiers in neuroscience · 2022Article
- Perspectives on Understanding Aberrant Brain Networks in Epilepsy.Frontiers in network physiology · 2022Article
- Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation.Frontiers in computational neuroscience · 2021Review
- More Than Spikes: On the Added Value of Non-linear Intracranial EEG Analysis for Surgery Planning in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global.Frontiers in physiology · 2021Article
- Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.Seizure · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowing when, where, and how seizures are initiated in large-scale epileptic brain networks remains a widely unsolved problem. Seizure precursors - changes in brain dynamics predictive of an impending seizure - can now be identified well ahead of clinical manifestations, but either the seizure onset zone or remote brain areas are reported as network nodes from which seizure precursors emerge. We aimed to shed more light on the role of constituents of evolving epileptic networks that recurrently transit into and out of seizures. We constructed such networks from more than 3200 hours of continuous intracranial electroencephalograms recorded in 38 patients with medication refractory epilepsy. We succeeded in singling out predictive edges and predictive nodes. Their particular characteristics, namely edge weight respectively node centrality (a fundamental concept of network theory), from the pre-ictal periods of 78 out of 97 seizures differed significantly from the characteristics seen during inter-ictal periods. The vast majority of predictive nodes were connected by most of the predictive edges, but these nodes never played a central role in the evolving epileptic networks. Interestingly, predictive nodes were entirely associated with brain regions deemed unaffected by the focal epileptic process. We propose a network mechanism for a transition into the pre-seizure state, which puts into perspective the role of the seizure onset zone in this transition and highlights the necessity to reassess current concepts for seizure generation and seizure prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.