ArticleScientific reports2019
Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High-Density Silicon Solar Cell Arrays.Advanced healthcare materials · 2026Article
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- A three-dimensional bipolar microneedle electrode array with local ground integrated at each sidewall for enhanced focal electric stimulation.Microsystems & nanoengineering · 2025Article
- Advances in artificial vision systems: a comprehensive review of technologies, applications, and future directions.Biomedical engineering letters · 2025Review
- Enhancing prosthetic vision by upgrade of a subretinal photovoltaic implant in situ.Nature communications · 2025Article
- 3D electronic implants in subretinal space: Long-term follow-up in rodents.Biomaterials · 2024Article
- Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ.bioRxiv : the preprint server for biology · 2024Article
- Focal stimulation of retinal ganglion cells using subretinal 3D microelectrodes with peripheral electrodes of opposite current.Biomedical engineering letters · 2024Article
- Three-dimensional electro-neural interfaces electroplated on subretinal prostheses.Journal of neural engineering · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- A novel GCaMP6f-RCS rat model for studying electrical stimulation in the degenerated retina.Frontiers in cell and developmental biology · 2024Article
- Three-dimensional electro-neural interfaces electroplated on subretinal prostheses.bioRxiv : the preprint server for biology · 2023Article
- Cellular migration into a subretinal honeycomb-shaped prosthesis for high-resolution prosthetic vision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Optimizing the fabrication of a 3D high-resolution implant for neural stimulation.Journal of biological engineering · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration.Sensors (Basel, Switzerland) · 2023Review
- Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats.Nature communications · 2022Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Photovoltaic implant simulator reveals resolution limits in subretinal prosthesis.Journal of neural engineering · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
High-resolution visual prostheses require small, densely packed pixels, but limited penetration depth of the electric field formed by a planar electrode array constrains such miniaturization. We present a novel honeycomb configuration of an electrode array with vertically separated active and return electrodes designed to leverage migration of retinal cells into voids in the subretinal space. Insulating walls surrounding each pixel decouple the field penetration depth from the pixel width by aligning the electric field vertically, enabling a decrease of the pixel size down to cellular dimensions. We demonstrate that inner retinal cells migrate into the 25 μm deep honeycomb wells as narrow as 18 μm, resulting in more than half of these cells residing within the electrode cavities. Immune response to honeycombs is comparable to that with planar arrays. Modeled stimulation threshold current density with honeycombs does not increase substantially with reduced pixel size, unlike quadratic increase with planar arrays. This 3-D electrode configuration may enable functional restoration of central vision with acuity better than 20/100 for millions of patients suffering from age-related macular degeneration.
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