Evidence map›Paper›PMID 31337812›Full record

ArticleScientific reports2019

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.

Xiang Liu, Dahn L Clemens, James A Grunkemeyer, Jeffrey D Price, Kelly O'Connell, Nora M Chapman, Peter Storz, Haitao Wen, Jesse L Cox, Whitney L Reid and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiang LiuDivision of Surgical Oncology, Department of Surgery, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. xli1@unmc.edu.
Dahn L ClemensDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.
James A GrunkemeyerMidwest laboratories, Omaha, NE, University of Nebraska Medical Center, Omaha, NE, USA.
Jeffrey D PriceDivision of Surgical Oncology, Department of Surgery, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Kelly O'ConnellEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Nora M ChapmanDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-3119-8772
Peter StorzDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, 32224, USA.
Haitao WenDepartment of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Jesse L CoxDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-4590-7381
Whitney L ReidDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Sarah ThayerDivision of Surgical Oncology, Department of Surgery, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
University of Nebraska Medical Center · USMayo Clinic in Florida · USThe Ohio State University · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Tissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1M
PKD1 signaling in the initiation of pancreatic cancerR01CA200572 · NCI · MAYO CLINIC JACKSONVILLE · PI STORZ, PETER · 2016 to 2021
$1.8M
PDG Links Stem Cell Niche to Pancreatic Epithelial Renewal, Repair and CancerR01CA169086 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THAYER, SARAH P · 2013 to 2017
$1.6M
Immunometabolism in microbial sepsis R01GM120496 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WEN, HAITAO · 2017 to 2021
$1.5M
NCI NIH HHS P30 CA036727NCI NIH HHS P50 CA127297NCI NIH HHS R01 CA169086NCI NIH HHS R01 CA200572NIGMS NIH HHS R01 GM120496
6 · The paper itself

Abstract

The Muc-1 oncoprotein is a tumor-associated mucin often overexpressed in pancreatic cancer. We report that knockout of Muc-1 reduced the degree of pancreatic inflammation that resulted from infection with Coxsackievirus B3 (CVB3) in a mouse model. CVB3-infected Muc-1-deficient (Muc-1

Indexed as

AnimalsCoxsackievirus InfectionsDisease Models, AnimalEnterovirus B, HumanInflammationMiceMice, KnockoutMucin-1PancreatitisReceptors, CCR2Ccr2 protein, mouseMucin-1Receptors, CCR2

Identifiers

PMID31337812
PMCPMC6650496
OpenAlexW2963878884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.