ArticleScientific reports2019
Genomic and molecular characterisation of Escherichia marmotae from wild rodents in Qinghai-Tibet plateau as a potential pathogen.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- From Cryptic Clade to Emerging Pathogen: Exploring the Evolutionary Divergence and Clinical Relevance ofMicroorganisms · 2026Review
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- Biodiversity and emerging infectious threats: the microbial dark matter of Southwest China.Frontiers in microbiology · 2026Review
- Carbapenem resistance in Escherichia marmotae: characterization of IncL plasmids carrying blaOXA-48.The Journal of antimicrobial chemotherapy · 2025Article
- Whole-genome characterization and antibiotic resistance phenotype ofMicrobiology spectrum · 2025Article
- Genome organization, virulence genes, and temperature-dependent motility of an emerging pathogen,Frontiers in microbiology · 2025Article
- New diagnostic methods forFrontiers in microbiology · 2025Article
- Genomic Characterization and Comparative Analysis of Streptococcus zhangguiae sp. nov. Isolated from the Respiratory Tract of Marmota Himalayana.Journal of microbiology (Seoul, Korea) · 2024Article
- Characterization and comparative analysis of the Escherichia marmotae M-12 isolate from bank vole (Myodes glareolus).Scientific reports · 2023Article
- Occurrence and temporal distribution of extended-spectrum β-lactamase-producingFrontiers in microbiology · 2023Article
- A novel phytopathogenFrontiers in cellular and infection microbiology · 2023Article
- Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau.Scientific reports · 2022Article
- EnteroBase: hierarchical clustering of 100 000s of bacterial genomes into species/subspecies and populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Article
- Whole-Genome Sequencing and Virulome Analysis of Escherichia coli Isolated from New Zealand Environments of Contrasting Observed Land Use.Applied and environmental microbiology · 2022Article
- The microbial ecology of Escherichia coli in the vertebrate gut.FEMS microbiology reviews · 2022Review
- Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia.Scientific reports · 2022Article
- Escherichia marmotae-a Human Pathogen Easily Misidentified as Escherichia coli.Microbiology spectrum · 2022Article
- Presence of Broad-Spectrum Beta-Lactamase-ProducingMicroorganisms · 2021Article
- Article
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16 authors.
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Abstract
Wildlife is a reservoir of emerging infectious diseases of humans and domestic animals. Marmota himalayana mainly resides 2800-4000 m above sea level in the Qinghai-Tibetan Plateau, and is the primary animal reservoir of plague pathogen Yersinia pestis. Recently we isolated a new species, Escherichia marmotae from the faeces of M. himalayana. In this study we characterised E. marmotae by genomic analysis and in vitro virulence testing to determine its potential as a human pathogen. We sequenced the genomes of the seven E. marmotae strains and found that they contained a plasmid that carried a Shigella-like type III secretion system (T3SS) and their effectors, and shared the same O antigen gene cluster as Shigella dysenterae 8 and E. coli O38. We also showed that E. marmotae was invasive to HEp-2 cells although it was much less invasive than Shigella. Thus E. marmotae is likely to be an invasive pathogen. However, E. marmotae has a truncated IpaA invasin, and lacks the environmental response regulator VirF and the IcsA-actin based intracellular motility, rendering it far less invasive in comparison to Shigella. E. marmotae also carried a diverse set of virulence factors in addition to the T3SS, including an IS1414 encoded enterotoxin gene astA with 37 copies, E. coli virulence genes lifA/efa, cif, and epeA, and the sfp gene cluster, Yersinia T3SS effector yopJ, one Type II secretion system and two Type VI secretion systems. Therefore, E. marmotae is a potential invasive pathogen.
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