ArticleNature communications2019
Conditional expression explains molecular evolution of social genes in a microbe.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Exploring cooperation among social pathogens: a computational perspective.FEMS microbiology reviews · 2026Review
- Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti.Nature ecology & evolution · 2025Article
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- Parallel evolution of the G protein-coupled receptor GrlG and the loss of fruiting body formation in the social amoeba Dictyostelium discoideum evolved under low relatedness.G3 (Bethesda, Md.) · 2023Article
- Reduced social function in experimentally evolvedProceedings. Biological sciences · 2023Article
- SOCfinder: a genomic tool for identifying social genes in bacteria.Microbial genomics · 2023Article
- Open questions in the social lives of viruses.Journal of evolutionary biology · 2023Review
- Signatures of kin selection in a natural population of the bacteriaEvolution letters · 2023Article
- The evolutionary patterns, expression profiles, and genetic diversity of expanded genes in barley.Frontiers in plant science · 2023Article
- Cooperation loci are more pleiotropic than private loci in the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Kin selection for cooperation in natural bacterial populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Conserved Serine Transporter SdaC Moonlights To Enable Self Recognition.Journal of bacteriology · 2022Article
- Kinship dynamics: patterns and consequences of changes in local relatedness.Proceedings. Biological sciences · 2021Review
- Inferring Adaptive Codon Preference to Understand Sources of Selection Shaping Codon Usage Bias.Molecular biology and evolution · 2021Article
- Ten recent insights for our understanding of cooperation.Nature ecology & evolution · 2021Review
- Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors.Molecular biology and evolution · 2021Article
- WildEcology and evolution · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
Conflict is thought to play a critical role in the evolution of social interactions by promoting diversity or driving accelerated evolution. However, despite our sophisticated understanding of how conflict shapes social traits, we have limited knowledge of how it impacts molecular evolution across the underlying social genes. Here we address this problem by analyzing the genome-wide impact of social interactions using genome sequences from 67 Dictyostelium discoideum strains. We find that social genes tend to exhibit enhanced polymorphism and accelerated evolution. However, these patterns are not consistent with conflict driven processes, but instead reflect relaxed purifying selection. This pattern is most likely explained by the conditional nature of social interactions, whereby selection on genes expressed only in social interactions is diluted by generations of inactivity. This dilution of selection by inactivity enhances the role of drift, leading to increased polymorphism and accelerated evolution, which we call the Red King process.
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