Evidence map›Paper›PMID 31337751›Full record

ArticleExperimental & molecular medicine2019

Acetate attenuates inflammasome activation through GPR43-mediated Ca

Mengda Xu, Zhengyu Jiang, Changli Wang, Na Li, Lulong Bo, Yanping Zha, Jinjun Bian, Yan Zhang, Xiaoming Deng

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Experimental & molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 122 citations in OpenAlex.

  1. Article
  2. Reversible alterations of brain acetate metabolism associated with alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  19. Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026
    Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mengda Xu *Faculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Zhengyu Jiang *Faculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Changli Wang *Faculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Na Li *Faculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Lulong BoFaculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Yanping ZhaFaculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Jinjun BianFaculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China.
Yan ZhangFaculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China. zhangyansmmu@163.com.
Xiaoming DengFaculty of Anesthesiology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China. deng_x@yahoo.com.
Second Military Medical University · CNChanghai Hospital · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31370865National Natural Science Foundation of China (National Science Foundation of China) 81600948National Natural Science Foundation of China (National Science Foundation of China) 81671887National Natural Science Foundation of China (National Science Foundation of China) 81671939National Natural Science Foundation of China (National Science Foundation of China) 81771697National Natural Science Foundation of China (National Science Foundation of China) 81772105
6 · The paper itself

Abstract

Acetate has been indicated to be elevated and to regulate inflammation in inflammatory and metabolic diseases. The inflammasome serves as a key component of immune homeostasis, and its dysregulation can lead to various inflammatory disorders. However, little is known about the effects of acetate on inflammasome activation and the underlying mechanism. Here, we demonstrate that acetate attenuates inflammasome activation via GPR43 in a Ca

Indexed as

AcetatesAnimalsAnti-Inflammatory AgentsAutophagyCalciumCytokinesEndotoxemiaInflammasomesInflammationMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPeritonitisReceptors, G-Protein-CoupledSignal TransductionAcetatesAnti-Inflammatory AgentsCalciumCytokinesFfar2 protein, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptors, G-Protein-Coupled

Identifiers

PMID31337751
PMCPMC6802670
OpenAlexW2963411084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.