Evidence map›Paper›PMID 31337735›Full record

ArticleThe Journal of experimental medicine2019

Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity.

James T Earnest, Katherine Basore, Vicky Roy, Adam L Bailey, David Wang, Galit Alter, Daved H Fremont, Michael S Diamond

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

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  8. Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates.Journal of controlled release : official journal of the Controlled Release Society · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

James T EarnestDepartment of Medicine, Washington University School of Medicine, St. Louis, MO.
Katherine BasoreDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Vicky RoyRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA.ORCID 0000-0002-5064-1098
Adam L BaileyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
David WangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Galit AlterRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA.
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, MO diamond@wusm.wustl.edu.ORCID 0000-0002-6646-6781

Funding

Specific and Broadly Active Monoclonal Antibody Therapeutics Against The FilovirusesU19AI142790 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SAPHIRE, ERICA OLLMANN · 2019 to 2023
$40.0M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
Antibody Based Therapeuticcs for Chikungunya VirusR01AI089591 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S · 2010 to 2014
$4.7M
Structural and functional basis of ultra potent CHKV neutralization by human mAbsR01AI114816 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2015 to 2019
$3.7M
NIAID NIH HHS R01 AI089591NIAID NIH HHS R01 AI114816NIAID NIH HHS U19 AI142790NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM139774
6 · The paper itself

Abstract

Despite causing outbreaks of fever and arthritis in multiple countries, no countermeasures exist against Mayaro virus (MAYV), an emerging mosquito-transmitted alphavirus. We generated 18 neutralizing mAbs against MAYV, 11 of which had "elite" activity that inhibited infection with EC

Indexed as

AlphavirusAlphavirus InfectionsAnimalsAntibodies, Monoclonal, Murine-DerivedAntibodies, NeutralizingAntibodies, ViralChlorocebus aethiopsFemaleHEK293 CellsHumansImmunoglobulin Fc FragmentsImmunoglobulin GMiceMice, Inbred BALB CMonocytesNeutrophilsAntibodies, Monoclonal, Murine-DerivedAntibodies, NeutralizingAntibodies, ViralImmunoglobulin Fc FragmentsImmunoglobulin G

Identifiers

PMID31337735
PMCPMC6781005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.