ArticleNeurology2019
Effect of coexisting vascular disease on long-term risk of recurrent events after TIA or stroke.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Mapping the Evidence: Central Sleep Apnea Syndromes During Sleep and Stroke-A Scoping Review.Revista de neurologia · 2026Article
- Serum calcium levels are independently associated with severe coronary artery stenosis combined with severe cerebral artery stenosis.BMC neurology · 2026Article
- Stroke, Cardiovascular Disease, and Dementia After Hospitalized TIA: The Atherosclerosis Risk in Communities Study.Neurology · 2025Article
- Identification of specific risk factors and predictive analytics for cardio-cerebral arterial stenosis: a comparative study utilizing framingham risk stratification insights.BMC neurology · 2025Article
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- Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023.Atherosclerosis plus · 2024Review
- Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex.Frontiers in neurology · 2024Article
- Article
- Factors affecting physician decision-making regarding antiplatelet therapy in minor ischemic stroke.Frontiers in neurology · 2022Article
- Development of a Nomogram for Predicting Asymptomatic Coronary Artery Disease in Patients with Ischemic Stroke.Current neurovascular research · 2022Article
- Impact of multimorbidity on risk and outcome of stroke: Lessons from chronic kidney disease.International journal of stroke : official journal of the International Stroke Society · 2021Article
- Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice.Translational stroke research · 2020Article
- Aspirin Resistance Affects Medium-Term Recurrent Vascular Events after Cerebrovascular Incidents: A Three-Year Follow-up Study.Brain sciences · 2020Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo determine whether patients with TIA or ischemic stroke with coexisting cardiovascular disease (i.e., history of coronary or peripheral artery disease) are still at high risk of recurrent ischemic events despite current secondary prevention guidelines.
methodsIn a population-based study in Oxfordshire, UK (Oxford Vascular Study), we studied consecutive patients with TIA or ischemic stroke for 2002-2014. Patients were treated according to current secondary prevention guidelines and we determined risks of coronary events, recurrent ischemic stroke, and major bleeding stratified by the presence of coexisting cardiovascular disease.
resultsAmong 2,555 patients (9,148 patient-years of follow-up), those (n = 640; 25.0%) with coexisting cardiovascular disease (449 coronary only; 103 peripheral only; 88 both) were at higher 10-year risk of coronary events than those without (22.8%, 95% confidence interval 17.4-27.9; vs 7.1%, 5.3-8.8;
conclusionsAs in older studies, patients with TIA/stroke with coexisting cardiovascular disease remain at high risk of recurrent ischemic events despite current management. More intensive lipid-lowering might therefore be justified, but benefit from increased antithrombotic treatment might be offset by the higher risk of extracranial bleeding.
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