Evidence map›Paper›PMID 31337708›Full record

ArticleThe Journal of biological chemistry2019

Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota

Clémence Balty, Alain Guillot, Laura Fradale, Clémence Brewee, Mylène Boulay, Xavier Kubiak, Alhosna Benjdia, Olivier Berteau

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  6. RadicalJournal of the American Chemical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clémence BaltyMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Alain GuillotMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Laura FradaleMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Clémence BreweeMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Mylène BoulayMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Xavier KubiakMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Alhosna BenjdiaMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France Alhosna.Benjdia@inra.fr.
Olivier BerteauMicalis Institute, ChemSyBio, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France Olivier.Berteau@inra.fr.ORCID 0000-0002-3434-5168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human microbiota plays a central role in human physiology. This complex ecosystem is a promising but untapped source of bioactive compounds and antibiotics that are critical for its homeostasis. However, we still have a very limited knowledge of its metabolic and biosynthetic capabilities. Here we investigated an enigmatic biosynthetic gene cluster identified previously in the human gut symbiont

Indexed as

Amino Acid SequenceBacteriocinsClostridium perfringensEubacterialesGastrointestinal MicrobiomeHumansMultigene FamilyPeptide BiosynthesisPeptidesProtein Processing, Post-TranslationalRibosomesSterile Alpha MotifSulfidesSymbiosisBacteriocinsPeptidesSulfidesantibioticsantimicrobial peptide (AMP)enzymemicrobiomenatural product biosynthesispeptide biosynthesisradicalradical AdoMet enzymeradical SAM enzymeRiPPruminococcinruminococcin C

Identifiers

PMID31337708
PMCPMC6779426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.