Observational studyPediatrics2019
Neurodevelopmental Outcomes of Preterm Infants With Retinopathy of Prematurity by Treatment.
Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Impact of anti-VEGF therapy versus laser therapy on mortality and treatment outcomes in retinopathy of prematurity: A systematic review and meta-analysis.Acta ophthalmologica · 2026Pooled it
- A Meta-Analysis of Neurodevelopmental Outcomes following Intravitreal Bevacizumab for the Treatment of Retinopathy of Prematurity.Neonatology · 2023Pooled it
- Neurodevelopmental outcomes following bevacizumab treatment for retinopathy of prematurity: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2021Pooled it
- Intravitreal Aflibercept vs Laser Therapy for Retinopathy of Prematurity: Two-Year Efficacy and Safety Outcomes in the Nonrandomized Controlled Trial FIREFLEYE next.JAMA network open · 2024Trial
- Short-term Outcomes After Very Low-Dose Intravitreous Bevacizumab for Retinopathy of Prematurity.JAMA ophthalmology · 2020Trial
- Neurodevelopmental Disorders in Infants Treated with Anti-VEGF Agents versus Laser Photocoagulation or Cryotherapy for Retinopathy of Prematurity.Ophthalmology science · 2026Article
- Retinopathy of Prematurity: Historical Evolution of Clinical Management and Medico-Legal Evaluation in Japan.Healthcare (Basel, Switzerland) · 2026Review
- Polyunsaturated Fatty Acid Balance Modulates Microglial State in a Murine Model of Oxygen-Induced Neovascularization.Nutrients · 2026Article
- Anti-VEGF versus laser therapy for retinopathy of prematurity: a systematic review and meta-analysis focusing on recurrence patterns and retreatment needs.International journal of retina and vitreous · 2026Article
- Article
- Off-label prescribing in ophthalmology: a retrospective analysis.Frontiers in pharmacology · 2026Article
- Yield of Early Examination for Aggressive Retinopathy of Prematurity: A Retrospective Study.Indian pediatrics · 2026Article
- Early developmental trajectory phenotypes for risk stratification of autism spectrum disorder in very preterm infants: a machine learning approach.Molecular autism · 2025Article
- Retinopathy of Prematurity and Risk of Structural Brain Abnormalities on Magnetic Resonance Imaging at Term Among Infants Born at Less Than or Equal to 32 Weeks of Gestation.The Journal of pediatrics · 2025Article
- Polyunsaturated fatty acid balance modulates microglial state in a murine model of oxygen-induced neovascularization.Research square · 2025Article
- Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity.FASEB bioAdvances · 2025Article
- Targeting adenosine APurinergic signalling · 2025Review
- Retinopathy of Prematurity (ROP): An Overview of Biomarkers in Various Samples for Prediction, Diagnosis, and Prognosis.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Innovative Use of Nanomaterials in Treating Retinopathy of Prematurity.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Long-term follow-up of the cognitive function in children after intravitreal ranibizumab for retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 13 institutions in 1 country.
Girija NatarajanDepartment of Pediatrics, Wayne State University, Detroit, Michigan; gnatara@med.wayne.edu.
Seetha ShankaranDepartment of Pediatrics, Wayne State University, Detroit, Michigan.
Tracy L NolenSocial, Statistical, and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Amaanti SridharSocial, Statistical, and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Kathleen A KennedyDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
Susan R HintzDivision of Neonatal and Developmental Medicine, Department of Pediatrics, School of Medicine, Stanford University and Lucile Packard Children's Hospital, Palo Alto, California.
Dale L PhelpsDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York.
Sara B DeMauroDepartment of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Marie G GantzSocial, Statistical, and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Abhik DasSocial, Statistical, and Environmental Sciences Unit, RTI International, Rockville, Maryland.
Rachel G GreenbergDepartment of Pediatrics, Duke University, Durham, North Carolina.
Noelle E YoungeDepartment of Pediatrics, Duke University, Durham, North Carolina.
Joseph M BlissDepartment of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Ruth SeabrookDepartment of Pediatrics, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio.
Pablo J SánchezDepartment of Pediatrics, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio.
Myra H WyckoffDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, Iowa; and.
Betty R VohrDepartment of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Rosemary D HigginsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
RTI International · USDuke University · USThe Ohio State University · USWayne State University · USWomen & Infants Hospital of Rhode Island · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USStanford University · USThe University of Texas Health Science Center at Houston · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Iowa · USUniversity of Pennsylvania · USUniversity of Rochester Medical Center · US
Funding
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3MNorth Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9MDuke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3MVITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI HEUBI, JAMES E. · 1994 to 2009
$20.6MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD040689 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI WYCKOFF, MYRA HELEN · 2001 to 2015
$5.6MNICHD Neonatal Research Network -- Cincinnati Clinical CenterUG1HD027853 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR · 2016 to 2026
$3.7MClinical Center for NICHD/Neonatal Research NetworkUG1HD068244 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Sara Bonamo DeMauro, Eric C Eichenwald · 2016 to 2026
$3.6MNICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORKUG1HD040689 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Myra Helen Wyckoff · 2016 to 2026
$3.5MNICHD Neonatal Research Network Clinical Center - Case Western Reserve UniversityUG1HD021364 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI Anna Maria Hibbs · 2016 to 2026
$3.5MNorth Carolina Clinical CenterUG1HD040492 · NICHD · DUKE UNIVERSITY · PI CHARLES Michael COTTEN, Matthew Laughon · 2016 to 2026
$3.4MNICHD Neonatal Research Network - Stanford UniversityUG1HD027880 · NICHD · STANFORD UNIVERSITY · PI Valerie Chock · 2016 to 2026
$3.3MNCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR001117NCRR NIH HHS M01 RR008084NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD068278NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087229NIDDK NIH HHS K23 DK120960
Abstract
objectiveAmong extremely preterm infants, we evaluated whether bevacizumab therapy compared with surgery for retinopathy of prematurity (ROP) is associated with adverse outcomes in early childhood.
methodsThis study was a retrospective analysis of prospectively collected data on preterm (22-26 + 6/7 weeks' gestational age) infants admitted to the
resultsThe cohort (
conclusionsIn this multicenter cohort of preterm infants, ROP treatment modality was not associated with differences in death or NDI, but the bevacizumab group had higher mortality and poor cognitive outcomes in early childhood. These data reveal the need for a rigorous appraisal of ROP therapy.
Indexed as
AdultAngiogenesis InhibitorsBevacizumabChild DevelopmentCohort StudiesFemaleHumansInfant, NewbornInfant, PrematureMaleNeurodevelopmental DisordersProspective StudiesRetinopathy of PrematurityRetrospective StudiesAngiogenesis InhibitorsBevacizumab
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.