Evidence map›Paper›PMID 31337428›Full record

Trial reportCancer imaging : the official publication of the International Cancer Imaging Society2019

PET/MRI and PET/CT hybrid imaging of rectal cancer - description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study.

Miriam K Rutegård, Malin Båtsman, Jan Axelsson, Patrik Brynolfsson, Fredrik Brännström, Jörgen Rutegård, Ingrid Ljuslinder, Lennart Blomqvist, Richard Palmqvist, Martin Rutegård and 1 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Cancer imaging : the official publication of the International Cancer Imaging Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03846882 (The Value of PET / MRI for the Assessment of Lymph Node Metastasis and Other Prognostic Factors in Patients With Rectal Cancer), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03846882 unknown statusnot on this map

The Value of PET / MRI for the Assessment of Lymph Node Metastasis and Other Prognostic Factors in Patients With Rectal Cancer

TypeobservationalSponsorRegion VästerbottenRan2015 to 2023Enrolled100ConditionsRectal Cancer, Lymph Node Metastases
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. [18F]FDG PET/MRI in rectal cancer.Annals of nuclear medicine · 2021
    Pooled it
  4. Rectal cancer: a methodological approach to matching PET/MRI to histopathology.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020
    Trial
  5. Review
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  9. Article
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  11. Article
  12. Review
  13. PET/MRI in colorectal and anal cancers: an update.Abdominal radiology (New York) · 2023
    Review
  14. Fundamentals of Bowel Cancer for Biomedical Engineers.Annals of biomedical engineering · 2023
    Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miriam K RutegårdDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, SE-901 85, Umeå, Sweden. miriam.rutegard@diagrad.umu.se.ORCID http://orcid.org/0000-0003-3510-2165
Malin BåtsmanDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Jan AxelssonDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, SE-901 85, Umeå, Sweden.
Patrik BrynolfssonDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, SE-901 85, Umeå, Sweden.
Fredrik BrännströmDepartment of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.
Jörgen RutegårdDepartment of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.
Ingrid LjuslinderDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Lennart BlomqvistDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, SE-901 85, Umeå, Sweden.
Richard PalmqvistDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Martin RutegårdDepartment of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.
Katrine RiklundDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, SE-901 85, Umeå, Sweden.

Funding

Medicinska fakulteten, Umeå Universitet VLL-757781Medicinska fakulteten, Umeå Universitet VLL-864711
6 · The paper itself

Abstract

purposeThe role of hybrid imaging using

methodsThis prospective cohort study, initiated in September 2016, is actively recruiting patients from Region Västerbotten in Sweden. This pilot study includes patients recruited and followed up until December 2017. All patients had a biopsy-verified rectal adenocarcinoma and underwent a minimum of one preoperative FDG-PET/CT and FDG-PET/MRI examination. These patients were referred to the colorectal cancer multidisciplinary team meeting at Umeå University Hospital. All available data were evaluated when making management recommendations. The clinical course was noted and changes consequent to PET imaging were described; surgical specimens underwent dedicated MRI for anatomical matching between imaging and histopathology.

resultsTwenty-four patients have so far been included in the study. Four patients were deemed unresectable, while 19 patients underwent or were scheduled for surgery; one patient was enrolled in a watch-and-wait programme after restaging. Consequent to taking part in the study, two patients were upstaged to M1 disease: one patient was diagnosed with a solitary hepatic metastasis detected using PET/CT and underwent metastasectomy prior to rectal cancer surgery, while one patient with a small, but metabolically active, lung nodulus experienced no change of management. PET/MRI did not contribute to any recorded change in patient management.

conclusionsThe RECTOPET study investigating the role of PET/CT and PET/MRI for preoperative staging of primary rectal cancer patients will provide novel data that clarify the value of adding hybrid to conventional imaging, and the role of PET/CT versus PET/MRI.

trial registrationNCT03846882 .

Indexed as

Magnetic Resonance ImagingMultimodal ImagingPositron Emission Tomography Computed TomographyAdenocarcinomaAdultAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeoplasm StagingRadiopharmaceuticalsRectal NeoplasmsFluorodeoxyglucose F18RadiopharmaceuticalsFDG-PET/CTFDG-PET/MRILymph nodesPET/CTPET/MRIRectal neoplasmRectal tumourStagingTumour deposits

Identifiers

PMID31337428
PMCPMC6651930

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.