Evidence map›Paper›PMID 31337427›Full record

ArticleBreast cancer research : BCR2019

Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy.

Manila Hada, Hannah Oh, Ruth M Pfeiffer, Roni T Falk, Shaoqi Fan, Maeve Mullooly, Michael Pollak, Berta Geller, Pamela M Vacek, Donald Weaver and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

Manila HadaNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA. manila.hada@nih.gov.ORCID 0000-0002-6960-5871
Hannah OhDivision of Health Policy and Management, College of Health Sciences, Korea University, Seoul, Republic of Korea.
Ruth M PfeifferNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Roni T FalkNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Shaoqi FanNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Maeve MulloolyRoyal College of Surgeons in Ireland, Dublin, Ireland.
Michael PollakMcGill University, Montreal, QC, Canada.
Berta GellerUniversity of Vermont and Vermont Cancer Center, Burlington, VT, USA.
Pamela M VacekUniversity of Vermont and Vermont Cancer Center, Burlington, VT, USA.
Donald WeaverUniversity of Vermont and Vermont Cancer Center, Burlington, VT, USA.
John ShepherdUniversity of Hawaii, Honolulu, Hawaii, USA.
Jeff WangGraduate School of Medicine, Hokkaido University, Sapporo, Japan.
Bo FanUniversity of California San Francisco, San Francisco, CA, USA.
Amir Pasha MahmoudzadehUniversity of California San Francisco, San Francisco, CA, USA.
Serghei MalkovUniversity of California San Francisco, San Francisco, CA, USA.
Sally HerschornUniversity of Vermont and Vermont Cancer Center, Burlington, VT, USA.
Louise A BrintonNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark E ShermanMayo Clinic, Jacksonville, FL, USA.
Gretchen L GierachNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USUniversity of Vermont · USUniversity of California, San Francisco · USHokkaido University · JPKorea University · KRMcGill University · CARoyal College of Surgeons in Ireland · IEUniversity of Hawaiʻi at Mānoa · USWinnMed · US

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
6 · The paper itself

Abstract

backgroundMammographic density (MD) is a strong breast cancer risk factor that reflects fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly understood. Insulin-like growth factor binding proteins (IGFBPs) are markers that may be associated with MD given their hypothesized role in breast carcinogenesis. IGFBPs sequester IGF-I, limiting its bioavailability. Prior studies have found positive associations between circulating IGF-I and the IGF-I:IGFBP-3 ratio and breast cancer risk. We evaluated the associations of IGF-I, IGFBP-3, and six other IGFBPs with MD.

methodsSerum IGF measures were quantified in 296 women, ages 40-65, undergoing diagnostic image-guided breast biopsy. Volumetric density measures (MD-V) were assessed in pre-biopsy digital mammograms using single X-ray absorptiometry. Area density measures (MD-A) were estimated by computer-assisted thresholding software. Age, body mass index (BMI), and BMI

resultsIGF-I and IGFBP-3 were not strongly associated with MD after BMI adjustment. In multivariable analyses among premenopausal women, IGFBP-2 was positively associated with both percent MD-V (β = 1.49, p value = 0.02) and MD-A (β = 1.55, p value = 0.05). Among postmenopausal women, positive relationships between IGFBP-2 and percent MD-V (β = 2.04, p = 0.003) were observed; the positive associations between IGFBP-2 and percent MD-V were stronger among lean women (BMI < 25 kg/m

conclusionsIn this comprehensive study of IGFBPs and MD, we observed a novel positive association between IGFBP-2 and MD, particularly among women with lower BMI. In concert with in vitro studies suggesting a dual role of IGFBP-2 on breast tissue, promoting cell proliferation as well as inhibiting tumorigenesis, our findings suggest that further studies assessing the role of IGFBP-2 in breast tissue composition, in addition to IGF-1 and IGFBP-3, are warranted.

Indexed as

Breast DensityImage-Guided BiopsyAdultBiomarkersBreast NeoplasmsCross-Sectional StudiesFemaleHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IMammographyMiddle AgedRisk FactorsBiomarkersIGF1 protein, humanInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IBreast densityBreast neoplasmInsulin-like growth factorInsulin-like growth factor binding proteinsMammographic density

Identifiers

PMID31337427
PMCPMC6651938
OpenAlexW2962866045

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.