ArticleBMC pregnancy and childbirth2019
Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.
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Who cites it
141 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Current trends in household food insecurity, dietary diversity, and stunting among children under five in Asia: a systematic review.Journal of global health · 2025Pooled it
- Risk factors associated with 31-day unplanned hospital readmission in newborns: a systematic review.European journal of pediatrics · 2023Pooled it
- The acceptability of implementing patient-reported measures in routine maternity care: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2023Pooled it
- Parental Age and the Risk of ADHD in Offspring: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Digital intervention for tokophobia: a randomized controlled trial of internet-based cognitive behavioral therapy on fear of childbirth and self-efficacy among Egyptian pregnant women.BMC pregnancy and childbirth · 2025Trial
- Identifying psychosocial predictors and developing a risk score for preterm birth among Kenyan pregnant women.BMC pregnancy and childbirth · 2025Trial
- Influence of maternal age on birth and infant outcomes at 6 months: a cohort study with quantitative bias analysis.International journal of epidemiology · 2023Trial
- Outcome evaluation of the Public Health New Brunswick Healthy Families, Healthy Babies targeted prenatal program on pregnancy and birth outcomes using a population-based retrospective administrative data cohort.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Elevated contractility drives implantation failure in mouse embryos from aged females.Nature cell biology · 2026Article
- Associations of Pre-Pregnancy and Prenatal Outdoor Nighttime Light, Green Space and Neighbourhood Walkability With Preterm Birth: Results From Ruian Birth Cohort Study.Paediatric and perinatal epidemiology · 2026Article
- Risk profiles of motor deficits in preterm infants: a cluster analysis approach.Pediatric research · 2026Article
- Association of pre-pregnancy abnormal glucose metabolism and insulin resistance with assisted reproductive technology outcomes and pregnancy complications in women with PCOS: a retrospective propensity score matching study.BMC pregnancy and childbirth · 2026Article
- Decomposition analysis and spatial change of age disparities in antenatal care utilisation among women with high-risk pregnancies in Nigeria.BMC pregnancy and childbirth · 2026Article
- Prevalence, indications, and preference of caesarean section deliveries among women attending primary health care units in Port-Said City, Egypt.The Journal of the Egyptian Public Health Association · 2026Article
- Risk factors associated with maternal complications of caesarean delivery in Rwanda: a retrospective cross-sectional study.BMC pregnancy and childbirth · 2026Article
- Interacting and joint effects of total gestational weight gain and the patterns on adverse pregnancy outcomes in twin pregnancy: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Socioeconomic determinants of extreme perinatal outcomes in Spain, 1996-2022.Scientific reports · 2026Article
- Preterm Birth in the West Bank, Palestine: Insights From a Hospital-Based Cohort Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Association of obstetrics and foetal ultrasound parameters with maternal serum Lamin A: A teaching institution-based cross-sectional study.Journal of family medicine and primary care · 2026Article
81 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increased potential for negative pregnancy outcomes in both extremes of reproductive age is a well-debated argument. The aim of this study was to analyze the prevalence and the outcome of pregnancies conceived at extreme maternal ages.
methodsThis retrospective study considered all single consecutive pregnancies delivered in a tertiary referral center between 2001 and 2014. Patients were categorized into 4 groups according to maternal age at delivery (< 17 years; 18-28 years; 29-39 years; > 40 years). The following outcomes were considered (amongst others): pregnancy-related hypertensive disorders (PRHDs), neonatal resuscitation (NR), neonatal intensive care unit (NICU) admission, periventricular leucomalacia (PVL), and grade 3 and 4 intraventicular hemorrhage (IVH).
resultsDuring the considered period 22,933 single pregnancies gave birth in our unit. We observed 71 women aged < 17 years, and 1552 aged > 40 years. In each year throughout the study period, there was a significant increment in maternal age of 0.041 years (95% CI 0.024-0.058) every new year. Multivariate analysis concluded out that maternal age over 40 years was an independent risk factor for preterm delivery (OR 1.36 95% CI 1.16-1.61, p < 0.05, PRHDs (OR 2.36 95% CI 1.86-3.00, p < 0.05), GDM (OR 1.71 95% CI 1.37-2.12, p < 0.05) cesarean section (OR 1.99 95% CI 1.78-2.23, p < 0.05), abnormal fetal presentation (OR 1.29 95% CI 1.03-1.61, p < 0.05), and fetal PVL (OR 3.32 95% CI 1.17-9.44, p < 0.05). We also observed that maternal age under 17 years or over 40 years was an independent risk factor for grade 3 or 4 neonatal IVH (OR 2.97 95% CI 1.24-7.14, p < 0.05).
conclusionsThese findings confirm a negative impact of extreme maternal ages on pregnancy. These results should be carefully taken into account by maternal care providers in order to inform women adequately, supporting them in understanding potential risks associated with their procreation choices, and to improve clinical surveillance.
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