Evidence map›Paper›PMID 31337282›Full record

ArticleThyroid : official journal of the American Thyroid Association2019

A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia.

Jin Zhou, Lauren R Waskowicz, Andrea Lim, Xiao-Hui Liao, Brian Lian, Hiroko Masamune, Samuel Refetoff, Brian Tran, Dwight D Koeberl, Paul M Yen

Open access · greenAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Targeting THR-β for MASLD: Mechanisms and Drug Development.Drug design, development and therapy · 2025
    Review
  8. Resmetirom: The First Disease-Specific Treatment for MASH.International journal of endocrinology · 2025
    Review
  9. Actions of thyroid hormones and thyromimetics on the liver.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  10. Drug discovery targeting thyroid hormone receptorActa pharmaceutica Sinica. B · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Emerging Therapies in Hypothyroidism.Annual review of medicine · 2024
    Review
  16. Review
  17. Review
  18. CS27109, A Selective Thyroid Hormone Receptor-International journal of endocrinology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jin Zhou1Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.
Lauren R Waskowicz2Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Andrea Lim1Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.
Xiao-Hui Liao3Department of Medicine, The University of Chicago, Chicago, Illinois.
Brian Lian4Viking Therapeutics, San Diego, California.
Hiroko Masamune4Viking Therapeutics, San Diego, California.
Samuel Refetoff3Department of Medicine, The University of Chicago, Chicago, Illinois.
Brian Tran4Viking Therapeutics, San Diego, California.
Dwight D Koeberl2Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Paul M Yen1Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.
Viking Therapeutics (United States) · USDuke-NUS Medical School · SGDuke University · USUniversity of Chicago · USDuke Medical Center · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
Investigating Autophagy in GSD-IaR01DK105434 · NIDDK · DUKE UNIVERSITY · PI KOEBERL, DWIGHT D · 2016 to 2019
$1.3M
NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R01 DK105434
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAutophagyDisease Models, AnimalFatty AcidsFatty LiverGlucose-6-PhosphataseGlycogenGlycogen Storage Disease Type ILiverMiceMice, KnockoutMitochondria, LiverOrganelle BiogenesisOrganophosphonatesOxidation-ReductionThyroid Hormone Receptors beta2-((3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl)-4-(3-chlorophenyl)-2-oxido(1,3,2)dioxaphosphonaneFatty AcidsGlucose-6-PhosphataseGlycogenOrganophosphonatesThyroid Hormone Receptors betaTriglyceridesautophagyglycogen storage disease type Ialipid metabolismmitochondrial biogenesisthyroid hormone mimeticVK2809

Identifiers

PMID31337282
PMCPMC6707038
OpenAlexW2962815903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.