ArticleCirculation2019
Association of
Open access · bronzeAbstract read
In one paragraph
Article in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.Kidney international · 2020Pooled it
- Genetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial.JAMA network open · 2026Trial
- Lessons learned: management of acute kidney injury during COVID-19.Renal failure · 2026Article
- Albuminuria Changes as a surrogate endpoint inmedRxiv : the preprint server for health sciences · 2026Article
- Epidemiology of cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.JAMA network open · 2026Article
- APOL1 G1 and G2 risk alleles modulate severity of diet-induced obesity in a transgenic mouse model.bioRxiv : the preprint server for biology · 2025Article
- Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population.Human genomics · 2025Article
- Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.Human genomics · 2025Article
- Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice.Clinical science (London, England : 1979) · 2025Article
- Article
- Conceptual frameworks for the integration of genetic and social epidemiology in complex diseases.Global epidemiology · 2024Article
- Systematic review and meta-analysis of the genetics of peripheral arterial disease.JVS-vascular science · 2024Review
- Article
- The metabolic effects of APOL1 in humans.Pflugers Archiv : European journal of physiology · 2023Review
- Article
- Phenome-Wide Association Study ofKidney international reports · 2022Article
- The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.Nature reviews. Nephrology · 2022Review
- APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.JAMA internal medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 12 institutions in 1 country.
Alexander G BickBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Elvis AkwoNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Cassianne Robinson-CohenNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Kyung LeeEdith Norse Rogers Memorial VA Medical Center, Bedford, MA (K.L., J.L., L.H., D.R.M., Q.S.).
Julie LynchEdith Norse Rogers Memorial VA Medical Center, Bedford, MA (K.L., J.L., L.H., D.R.M., Q.S.).
Themistocles L AssimesPalo Alto VA Health Care, CA (T.L.A., H.F., J.S.L., H.T., P.S.T.).
Scott DuVallVA Informatics and Computing Infrastructure, Salt Lake City, UT (J.L., S.D.).
Todd EdwardsNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Huaying FangPalo Alto VA Health Care, CA (T.L.A., H.F., J.S.L., H.T., P.S.T.).
S Matthew FreibergNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Ayush GiriNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Jennifer E HuffmanBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Jie HuangBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Leland HullBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Rachel L KemberCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
Derek KlarinBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Jennifer S LeePalo Alto VA Health Care, CA (T.L.A., H.F., J.S.L., H.T., P.S.T.).
Michael LevinCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
Donald R MillerEdith Norse Rogers Memorial VA Medical Center, Bedford, MA (K.L., J.L., L.H., D.R.M., Q.S.).
Pradeep NatarajanMassachusetts General Hospital, Boston (A.G.B., D.K., P.N., S.K.).
Danish SaleheenCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
Qing ShaoEdith Norse Rogers Memorial VA Medical Center, Bedford, MA (K.L., J.L., L.H., D.R.M., Q.S.).
Yan V SunAtlanta VA Medical Center, GA (Y.V.S., P.W.W.).
Hua TangPalo Alto VA Health Care, CA (T.L.A., H.F., J.S.L., H.T., P.S.T.).
Otis WilsonNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Kyong-Mi ChangCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
Kelly ChoBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
John ConcatoVA Connecticut HealthCare System, New Haven (J.C.).
J Michael GazianoBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Sekar KathiresanMassachusetts General Hospital, Boston (A.G.B., D.K., P.N., S.K.).
Christopher J O'DonnellBoston VA Healthcare System, MA (A.G.B., J.E.H., J.H., L.H., D.K., K.C., J.M.G., C.J.O.).
Daniel J RaderCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
Philip S TsaoPalo Alto VA Health Care, CA (T.L.A., H.F., J.S.L., H.T., P.S.T.).
Peter W WilsonAtlanta VA Medical Center, GA (Y.V.S., P.W.W.).
Adriana M HungNashville VA Medical Center, TN (E.A., C.R.-C., T.E., S.M.F., A.G., O.W., A.M.H.).
Scott M DamrauerCorporal Michael Crescenz VA Medical Center, Philadelphia, PA (R.L.K., M.L., D.S., K.-M.C., D.J.R., S.M.D.).
VA Million Veteran Program
Nashville VA Medical Center · USPhiladelphia VA Medical Center · USVA Palo Alto Health Care System · USBroad Institute · USEdith Nourse Rogers Memorial Veterans Hospital · USVA Boston Healthcare System · USEmory University · USHarvard University · USBoston University · USMassachusetts College of Pharmacy and Health Sciences · USVA Connecticut Healthcare System · USVA Salt Lake City Healthcare System · US
Funding
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3MWhole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7MPharmacogenomics of risk factors and therapies outcomes for kidney diseaseI01BX003360 · VA · VETERANS HEALTH ADMINISTRATION · PI HUNG, ADRIANA · 2017 to 2020
–Genetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–Regulatory Role of MicroRNAs in Aging-related Abdominal Aortic Aneurysm DiseaseI01BX002641 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI TSAO, PHILIP S · 2015 to 2019
–Precision Cardio-Metabolic Phenotyping for Genetic Discovery and Risk PredictionIK2CX001780 · VA · PHILADELPHIA VA MEDICAL CENTER · PI DAMRAUER, SCOTT MICHAEL · 2018 to 2023
–Dysmetabolism of Chronic Kidney Disease and Vascular HealthI01CX000982 · VA · VETERANS HEALTH ADMINISTRATION · PI HUNG, ADRIANA · 2015 to 2018
–Cardiovascular Disease Risk Factors, Prevalent Cardiovascular Disease, and Genetics in the Million Veteran ProgramI01BX003340 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2017 to 2017
–BLRD VA I01 BX002641BLRD VA I01 BX003340BLRD VA I01 BX003360BLRD VA I01 BX003362BLRD VA I01 BX004821CSRD VA I01 CX000982CSRD VA I01 CX001897CSRD VA IK2 CX001780NHLBI NIH HHS R01 HL142711NICHD NIH HHS K12 HD043483
Abstract
backgroundApproximately 13% of black individuals carry 2 copies of the apolipoprotein L1 (
methodsWe performed a time-to-event analysis of retrospective electronic health record data using Cox proportional hazard and competing-risks Fine and Gray subdistribution hazard models. The primary exposure was
resultsAmong 30 903 black Million Veteran Program participants, 3941 (13%) carried the 2
conclusions
Indexed as
Black or African AmericanGenotypeAdultAllelesApolipoprotein L1Coronary Artery DiseaseElectronic Health RecordsFemaleGenetic Predisposition to DiseaseHumansIncidenceMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseasePolymorphism, GeneticAPOL1 protein, humanApolipoprotein L1apolipoprotein L1cardiovascular diseasesgeneticsrenal insufficiency, chronic
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.